世界中医药2025，Vol.20Issue(18)：3253-3259,7.DOI:10.3969/j.issn.1673-7202.2025.18.010
协日嘎-4对2型糖尿病大鼠血糖血脂调节及肠道菌群的影响
Effects of Xieriga-4 on Blood Glucose and Lipid Regulation and Intestinal Flora in Type 2 Diabetic Rats
摘要
Abstract
Objective:To investigate the protective effects of Xieriga-4 on rats with type 2 diabetes mellitus(T2DM)and its influ-ence on glucose and lipid metabolism as well as intestinal flora.Methods:A T2DMrat model was established by intraperitoneal in-jection of streptozotocin(STZ)after 8 weeks of high-sugar and high-fat diet feeding.Successfully modeled rats were divided into a normal control group,a metformin group,and Xieriga-4 high-(5.04 g/kg),medium-(2.52 g/kg),and low-dose(1.26 g/kg)groups,and were administered the corresponding treatments by gavage for 4 consecutive weeks.Body weight and biochemical indi-ces,including fasting blood glucose(FBG),triglycerides(TG),and total cholesterol(TC),were measured.Changes in intestinal flo-ra were analyzed using 16S rDNA high-throughput sequencing.Results:Xieriga-4 significantly reduced FBG levels in T2DM rats(P<0.05),effectively attenuated body weight loss(P<0.05),and decreased TG,TC,and high-density lipoprotein(HDL)levels(P<0.05).Regarding intestinal flora,Xieriga-4 significantly increased the relative abundance of Peptostreptococcaceae and Lacto-bacillus(P<0.05),while reducing Roseburia(P<0.05).Compared with the model group,the treatment groups showed increased relative abundance of Firmicutes(0.806 4±0.106 2)and Lactobacillales(0.421 9±0.265 2),and decreased relative abundance of Actinobacteria(0.143 0±0.067 0)and Clostridia(0.263 2±0.104 9).Conclusion:Xieriga-4 exerts regulatory effects on blood glucose and lipid metabolism in STZ-induced T2DMrats,and its mechanism may be associated with the modulation of intesti-nal flora imbalance.关键词
协日嘎-4/2 型糖尿病/空腹血糖/血脂/胰岛素抵抗/肠道菌群/16SrDNA高通量测序/大鼠Key words
Xieriga-4/Type 2 diabetes/Fasting blood glucose/Blood lipid/Insulin resistance/Intestinal flora/16SrDNA high-throughput sequencing/Rat分类
医药卫生引用本文复制引用
胡伊力格其,图雅,胡德力根,安其力木格,于淑娟,白小梅..协日嘎-4对2型糖尿病大鼠血糖血脂调节及肠道菌群的影响[J].世界中医药,2025,20(18):3253-3259,7.基金项目
国家自然科学基金面上项目(82274212) （82274212）
内蒙古自治区自然科学基金项目(2025MS08130) （2025MS08130）
内蒙古民族大学中药学(蒙药学)重点学科建设项目(ZYX005) （蒙药学）
蒙医药研发工程教育部重点实验室开放基金项目(MDK2024025) （MDK2024025）
