日用化学工业（中英文）2026，Vol.56Issue(1)：73-81,9.DOI:10.3969/j.issn.2097-2806.2026.01.009
柞蚕丝素肽脂质体的制备及其抗光损伤作用研究
Study on the preparation of tussah silk fibroin peptide liposomes and their anti-photodamage effects
摘要
Abstract
A preparation process of tussah silk fibroin peptide liposomes with high encapsulation efficiency and suitable particle size was established by the reverse rotary evaporation method,and their anti-photodamage effect was evaluated in this study.The results show that the optimal encapsulation effect of tussah silk fibroin peptide liposomes is achieved by optimizing the single factor test to ascertain the preparation parameters of the mass ratio of cholesterol to lecithin of 1∶11,the aqueous phase volume of 3 mL,the pH of PBS solution of 8.0,the first ultrasound of 3 min,the second ultrasound of 5 min,and the emulsification temperature of 40℃.The tussah silk fibroin peptide liposomes are capable of ameliorating the photodamage to mouse embryonic fibroblasts by repairing collagen,enhancing anti-oxidation and exerting anti-inflammatory effects.Ultraviolet damage of zebrafish is alleviated by reducing reactive oxygen species(ROS)levels and repairing the tail fin.This study confirms the potential of tussah silk fibroin peptide liposomes in resisting skin photodamage,thereby rendering them suitable for application in skin care products.关键词
柞蚕丝素肽/脂质体/抗氧化/抗炎/光损伤修复Key words
tussah silk fibroin peptide/liposome/antioxidant/anti-inflammatory/photodamage repair分类
化学化工引用本文复制引用
米锐,李学军,王林美,陈星合,贾心悦,都兴范..柞蚕丝素肽脂质体的制备及其抗光损伤作用研究[J].日用化学工业（中英文）,2026,56(1):73-81,9.基金项目
财政部和农业农村部:国家现代农业产业技术体系资助 （）
辽宁省农业科学院院长基金项目(2021QN2002) （2021QN2002）
辽宁省农科院学科建设计划(2025XKJS8579) （2025XKJS8579）
