肿瘤预防与治疗2026，Vol.39Issue(1)：21-27,7.DOI:10.3969/j.issn.1674-0904.2026.01.004
甲状腺功能与甲状腺癌的因果关系:双样本孟德尔随机化分析
Causal Association between Thyroid Function and Thyroid Cancer:A Two-Sample Mendelian Randomization Study
摘要
Abstract
Objective:This study aims to investigate the causal relationship between five thyroid function parameters and thyroid cancer using mendelian randomization(MR).Methods:The GWAS summary statistics for thyroid function were ac-quired from the IEU OpenGWAS database.Data for thyroid cancer were extracted from both the IEU OpenGWAS database and the FinnGen database.We performed a two-sample Mendelian randomization analysis primarily using the inverse-vari-ance weighted method,supplemented by four additional analytical approaches:the weighted median estimator,MR-Egger re-gression,the simple mode,and the weighted mode.In addition,horizontal pleiotropy was assessed using the MR-Egger in-tercept test and the MR-PRESSO test.Heterogeneity and sensitivity of the results were evaluated by the Cochran's Q test and leave-one-out analysis,respectively.A reverse MR a-nalysis was also conducted.Results:The MR analysis showed that elevated levels of thyroid peroxidase(TPO)were associ-ated with a lower risk of follicular thyroid cancer(FTC)(OR=0.504,95%CI:0.299～0.848,P=0.010).Neither the MR-Egger intercept test(P=0.757)nor the MR-PRES-SO global test(P=0.973)indicated evidence of horizontal pleiotropy.No significant heterogeneity was detected by Coch-ran's Q test(P=0.963).The reverse MR Analysis showed that there was no significant correlation between FTC and TPO(P>0.05).The functional enrichment analysis showed that TPO was primarily linked to the cell adhesion and cytokine-cy-tokine receptor interaction signaling pathways.Conclusion:High levels of TPO may reduce the risk of FTC.关键词
甲状腺功能/甲状腺过氧化物酶/甲状腺癌/孟德尔随机化/因果关系Key words
Thyroid function/Thyroid peroxidase(TPO)/Thyroid cancer/Mendelian randomization/Causal relationship分类
医药卫生引用本文复制引用
杨甜,李钰博,吴昊,刘铭,朱剑军..甲状腺功能与甲状腺癌的因果关系:双样本孟德尔随机化分析[J].肿瘤预防与治疗,2026,39(1):21-27,7.基金项目
This study was supported by grants from Science and Technology Department of Shanxi Province(No.2023021211114)and Shanxi Provincial Education Department(No.BYJL047). 山西省应用基础研究项目(编号:2023 021211114) （No.2023021211114）
山西省高等教育"百亿工程"科技引导专项(编号:BYJL047) （编号:BYJL047）
