摘要
Abstract
Objective To compare the hemodynamic changes and safety of fospropofol disodium and propofol during anesthesia induction in patients undergoing painless endobronchial ultrasound-guided transbronchial needle aspiration(EBUS-TBNA).Methods Sixty-eight patients scheduled for elective painless EBUS-TBNA,aged 40～65 years with ASA physical status Ⅰ-Ⅲ,were enrolled and randomly allocated(1∶1)to the fospropofol diso-dium group(F group,n=34)or the propofol group(P group,n=34)using a random number table.Anesthesia induction was performed with intravenous sufentanil(0.3 μg/kg),followed by fospropofol disodium(12.5 mg/kg,F group)or propofol(2 mg/kg,P group)within 1 min.Rocuronium(0.6 mg/kg)was administered when the modi-fied observer′s assessment of alertness/sedation scale(MOAA/S)score was ied observerd observerhen the modified observerd transbronchial needle aventilation.Mean arterial pressure(MAP),heart rate(HR),and bispectral index(BIS)were recorded at six time points:entering the operating room(T0),1 min after induction(T1),immediately after laryngeal mask insertion(T2),bronchoscope passing through the glottis(T3),at the end of the EBUS-TBNA procedure(T4),and 3 min after extubation(T5).Intraoperative sedative and vasoactive drug consumption,sedation success rate,and incidence of adverse events were also assessed.Results Compared with the P group,the F group showed significantly higher MAP at T1 and T4(P<0.05),a lower incidence of intraoperative hypotension(P<0.05),and reduced total ephedrine use(P<0.05).The F group had a significantly longer time to loss of consciousness(P<0.05),higher incidence of paresthesia(P<0.05),and lower incidence of injection pain(P<0.01).No significant differences were observed between groups in BIS,HR,sedation success rate,recovery time,or incidence of bradycardia and tachycardia(all P>0.05).Conclusion Compared with propofol,fospropofol disodium provides more stable hemodynamics during general anesthesia for EBUS-TBNA,significantly reducing the incidence of hypotension and injection pain;however,it has a longer induction time and is associated with risks such as skin pruritus and paresthesia.关键词
磷丙泊酚二钠/超声引导下经支气管针吸活检术/全身麻醉/血流动力学Key words
fospropofol disodium/endobronchial ultrasound-guided transbronchial needle aspiration/general anesthesia/hemodynamics分类
医药卫生
