实用中医内科杂志2026，Vol.40Issue(1)：1-9,9.DOI:10.13729/j.issn.1671-7813.Z25051506
基于骨钙素调控探讨中医药防治骨质疏松症研究进展与分子机制
Research Progress and Molecular Mechanisms of Traditional Chinese Medicine in Osteoporosis Prevention and Treatment:Focus on Osteocalcin Regulation
摘要
Abstract
Osteocalcin(OCN),as a specific secretory protein of osteoblasts,is not only a biomarker for diagnosing osteoporo-sis(OP),but its carboxylation-modulated"bone endocrine"effect also provides a new target for the treatment of metabolic bone diseases.This article retrieves relevant literature from databases such as PubMed and China National Knowledge Infrastruc-ture(CNKI)from January 2000 to April 2025,focusing on the"pathway activation-OCN expression-bone volume increase"phenotype,and concentrating on the molecular mechanism of traditional Chinese medicine regulating OCN expression to improve OP.The results show that the characteristics of multi-target regulation of OCN signaling network by traditional Chinese medicine are highly consistent with the complexity of OP pathology.However,most current experiments on OCN mainly focus on changes in expression levels,and the precise regulatory mechanism of its signaling pathway still needs to be deeply analyzed by combining metabolomics,organoid models,and other technologies.This article provides ideas and theoretical support for the research of pre-cise intervention of OP by traditional Chinese medicine through reviewing such literature.关键词
骨钙素/骨质疏松症/中医药/研究进展/分子机制Key words
osteocalcin/osteoporosis/traditional Chinese medicin/research progress/molecular mechanisms分类
医药卫生引用本文复制引用
杨昱,姚啸生,戚晓楠,崔海舰,吕奕伯,蒋逸凡..基于骨钙素调控探讨中医药防治骨质疏松症研究进展与分子机制[J].实用中医内科杂志,2026,40(1):1-9,9.基金项目
国家自然科学基金青年科学基金项目(82305275) （82305275）
辽宁省教育厅科学技术研究青年项目(JYTQN2023456) （JYTQN2023456）
辽宁省博士科研启动基金计划项目(2025-BS-0707) （2025-BS-0707）
