世界中医药2025，Vol.20Issue(18)：3363-3368,6.DOI:10.3969/j.issn.1673-7202.2025.18.026
胆汁酸介导炎症反应在胆汁淤积性肝损伤中的作用机制
Mechanisms of Bile Acids-mediated Inflammatory Responses in Cholestatic Liver Injury
摘要
Abstract
Cholestatic liver injury(CLI)is liver damage caused by the excessive accumulation of bile acids(BAs),the major com-ponents of bile,in the body due to various factors.Without timely intervention,persistent CLI can further progress to liver fibrosis,cirrhosis,liver failure,and even death.The pathogenesis of CLI is complex,and BAs-mediated inflammatory responses play an im-portant role in its development.BAs induce inflammatory responses in hepatocytes,cholangiocytes,neutrophils,and macrophages,thereby leading to the occurrence and progression of CLI.关键词
胆汁淤积性肝损伤/胆汁酸/炎症反应/肝细胞/胆管细胞/中性粒细胞/巨噬细胞/作用机制Key words
Cholestatic liver injury/Bile acids/Inflammatory response/Hepatocytes/Cholangiocytes/Neutrophils/Macropha-ges/Mechanism分类
医药卫生引用本文复制引用
唐银佩,朱正望,朱平生..胆汁酸介导炎症反应在胆汁淤积性肝损伤中的作用机制[J].世界中医药,2025,20(18):3363-3368,6.基金项目
国家自然科学基金面上项目(82074340) （82074340）
河南省"双一流"创建学科中医学科学研究专项(HSRP-DFCTCM-2023-1-19) （HSRP-DFCTCM-2023-1-19）
