外科理论与实践2025，Vol.30Issue(6)：494-502,9.DOI:10.16139/j.1007-9610.2025.06.07
肥胖显著增加勃起功能障碍风险:一项基于观察性研究的荟萃分析
Obesity significantly increases the risk of erectile dysfunction:a meta-analysis based on observational studies
姬阆 1郝少龙 2孙海涛 2孙武青 2马纪红 3白日星 2韩威1
作者信息
- 1. 首都医科大学附属北京潞河医院中心实验室,北京 101149
- 2. 首都医科大学附属北京潞河医院普外科,北京 101149
- 3. 首都医科大学附属北京潞河医院医疗保健病区,北京 101149
- 折叠
摘要
Abstract
Objective To quantify the association between obesity and erectile dysfunction(ED)risk through a meta-analysis.Methods Following PRISMA guidelines,systematic searches of Chinese and English databases(up to March 2025)were conducted to include observational studies(cohort,cross-sectional,case-control).Adjusted effect sizes(OR and 95%CI)were extracted.Study quality was assessed using the Agency for Healthcare Research and Quality(AHRQ)scale,and a random-effects model was applied to pool effect sizes.Subgroup analyses(geographic region,obesity definitions)and sensitivity analyses were performed to validate robustness.Results Ten studies(n=230 744),including nine cross-sectional studies,were included.The meta-analysis revealed that obesity significantly increased ED risk(random-effects OR=1.80,95%CI:1.29-2.51),with high heterogeneity(I²=99.9%).Subgroup analyses indicated stronger associations in USA populations(OR=2.10,95%CI:1.23-3.60)than in Chinese populations(OR=1.16,95%CI:1.05-1.28).The highest effect size was observed when using BMI≥25 kg/m³ as the obesity threshold(OR=3.05,95%CI:2.06-4.51).Sensitivity analyses confirmed robust results(OR:1.60-1.94 after excluding any single study).Conclusions Obesity is a critical risk factor for ED,with effect strength influenced by geographic region and obesity definitions.Interventions targeting BMI≥30 kg/m² in Western populations and metabolic risks at BMI≥25 kg/m³ in Asian populations are recommended.关键词
肥胖/勃起功能障碍/荟萃分析/观察性研究Key words
Obesity/Erectile dysfunction(ED)/Meta-analysis/Observational studies分类
医药卫生引用本文复制引用
姬阆,郝少龙,孙海涛,孙武青,马纪红,白日星,韩威..肥胖显著增加勃起功能障碍风险:一项基于观察性研究的荟萃分析[J].外科理论与实践,2025,30(6):494-502,9.
