外科理论与实践2025，Vol.30Issue(6)：509-516,8.DOI:10.16139/j.1007-9610.2025.06.09
囊液性状可预测胰腺导管内乳头状黏液性肿瘤的良、恶性
Characteristics of cyst fluid can predict the benign or malignant nature of intraductal papillary mucinous neo-plasms
王敬源 1范嘉裕 1张平平 1马洪运 2陈颖 3李刚 2金震东 1金钢 2王凯旋1
作者信息
- 1. 海军军医大学长海医院消化内科,上海 200433
- 2. 海军军医大学长海医院肝胆胰脾外科,上海 200433
- 3. 海军军医大学长海医院病理科,上海 200433
- 折叠
摘要
Abstract
Objective To investigate the predictive ability of cyst fluid characteristics for malignant intraductal papillary mucinous neoplasms(IPMNs).Methods We prospectively collected fresh cyst fluid from patients undergoing pancreatic resection at the Department of Hepatobiliary Pancreatic Spleen Surgery,Changhai Hospital,Shanghai,from September 2023 to December 2024,who were ultimately pathologically confirmed with IPMN.We assessed the characteristics of cyst fluid,including viscosity,clarity,and color,and explored its predictive performance for benign or malignant.Results A total of 40 patients with IPMN were included.The sensitivity of the string sign(+)for diagnosing high-grade dysplasia/invasive carcinoma(HGD/IC)was 90.9%,specificity was 92.9%,and accuracy was 76.0%.The cyst fluid of intestinal-type IPMN often exhibited a gelatinous consistency,and there was no significant difference in the distribution of gelatinous consistency between the HGD/IC group and the low-grade dysplasia(LGD)group.There were no significant differences in CEA,glucose,and amylase levels in the cyst fluid between the HGD/IC group and the LGD group.Conclusions The characteristics of pancreatic cyst fluid,especially viscosity,can effectively predict the benign or malignant nature of IPMN.关键词
胰腺导管内乳头状黏液性肿瘤/囊液性状/拉丝实验/形态学亚型/异型增生等级Key words
Intraductal papillary mucinous neoplasm(IPMN)/Characteristics of cyst fluid/String sign/Morphological subtype/Grade of dysplasia分类
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王敬源,范嘉裕,张平平,马洪运,陈颖,李刚,金震东,金钢,王凯旋..囊液性状可预测胰腺导管内乳头状黏液性肿瘤的良、恶性[J].外科理论与实践,2025,30(6):509-516,8.
