外科理论与实践2025，Vol.30Issue(6)：517-523,7.DOI:10.16139/j.1007-9610.2025.06.10
胆道恶性肿瘤晚期免疫检查点抑制剂相关性肺炎的临床评估和处理(附3例报告)
Clinical evaluation and management of checkpoint inhibitor pneumonitis with advanced biliary tract cancer:a report of 3 cases
摘要
Abstract
Objective To report cases of checkpoint inhibitor pneumonitis(CIP)in patients with advanced biliary tract cancer,aiming to provide additional approaches for the assessment,treatment,and monitoring of this condition.Methods Three patients developed oxygen desaturation and interstitial lung lesions during chemotherapy combined with immunotherapy,and were diagnosed with CIP in collaboration with the respiratory department.Antitumor therapy was discontinued in the acute phase,and glucocorticoids were administered,with regular monitoring of disease progression.During follow-up,case 1 developed lung metastasis;case 2 showed improvement;case 3 had concurrent infection and tumor progression.Results Glucocorticoids improved lung lesions and hypoxic symptoms in patients with CIP,but attention should be paid to the potential for concurrent infections and tumor progression.Conclusions Comprehensive assessment and early identification of CIP are crucial for patients with advanced biliary tract cancer.For those with recurrent symptoms after glucocorticoid therapy,timely and accurate adjustment of the treatment regimen is essential.关键词
胆道恶性肿瘤晚期/免疫相关不良反应/免疫检查点抑制剂相关性肺炎Key words
Advanced biliary tract cancer/Immune-related adverse events(irAE)/Checkpoint inhibitor pneumonitis(CIP)分类
医药卫生引用本文复制引用
孙学英,吴彬,蒋逸飞,廖卓君,赵金燕,周颖,张舒龙,王燕,刘厚宝..胆道恶性肿瘤晚期免疫检查点抑制剂相关性肺炎的临床评估和处理(附3例报告)[J].外科理论与实践,2025,30(6):517-523,7.基金项目
上海市徐汇区高原学科建设项目(SHXHZDXK202323) （SHXHZDXK202323）
尖峰学科建设项目(SHXHZDXK202304) （SHXHZDXK202304）
徐汇区公共卫生体系建设三年行动计划(2023-2025年) （2023-2025年）
