摘要
Abstract
Objectives:To analyze the factors influencing the outcomes of intrauterine insemination(IUI)assisted pregnancy in patients with diminished ovarian reserve(DOR).
Methods:A retrospective analysis was conducted on the data of DOR patients who received IUI treatment at the Reproductive Medicine Center of China-Japan Union Hospital of Jilin University and the Reproductive Medicine Center of Jilin Provincial People's Hospital from January 2021 to February 2025.A total of 2 357 cycles of 1 221 DOR patients were included.The IUI-assisted pregnancy outcomes of DOR patients were observed.Clinical data from different outcome groups were compared.Multivariate logistic analysis was conducted to analyze the factors influencing the IUI-assisted pregnancy outcomes of patients with DOR.
Results:The clinical pregnancy rate of patients with DOR was 11.96％(282/2 357).There were no statistically significant differences in male and female age,male and female educational levels and place of residence between the clinical pregnancy group and the non-clinical pregnancy group(P＞0.05).Compared with the non-clinical pregnancy group,the female body mass index(BMI)in the clinical pregnancy group was lower,the duration of infertility was shorter,the anti-Müllerian hormone(AMH)level was higher,the basal follicle-stimulating hormone(FSH)level was lower,and the basal antral follicle count(AFC)was greater(P＜0.001).There was a statistically significant difference in the cycle protocols between the two groups(P＜0.05),and the number of dominant follicles in the clinical pregnancy group was significantly higher than that of the non-pregnancy group(P＜0.001).Logistic regression analysis showed the infertility duration[OR=3.557,95％CI(1.464,8.645)],AMH level[OR=0.601,95％CI(0.247,1.461)],AFC[OR=0.506,95％CI(0.208,1.229)]and the number of dominant follicles[OR=0.443,95％CI(0.182,1.076)]were independent factors influencing the IUI-assisted pregnancy outcomes in DOR patients(P＜0.05).
Conclusions:The duration of infertility is a risk factor for the outcomes of IUI assisted pregnancy,and the clinical pregnancy rates are lower among those with longer infertility duration;AMH,AFC and the number of dominant follicles are protective factors for the outcomes of IUI assisted pregnancy.关键词
卵巢储备功能下降/宫腔内人工授精/临床妊娠率/影响因素Key words
Decreased ovarian reserve/Intrauterine insemination/Clinical pregnancy rate/Influencing factor分类
医药卫生
