生殖医学杂志2026，Vol.35Issue(1)：64-70,7.DOI:10.3969/j.issn.1004-3845.2026.01.010
唾液晚期糖基化终产物用于无创监测妊娠期糖尿病血糖控制:妊娠特异性临界值体系建立
Salivary advanced glycation end products(s-AGEs)for non-invasive monitoring of GDM blood glucose control:establishment of pregnancy-specific critical value system
摘要
Abstract
Objectives:To establish a pregnancy-specific critical value system for non-invasive monitoring of blood glucose control in gestational diabetes mellitus(GDM)based on salivary advanced glycation end products(s-AGEs). Methods:This study is a prospective randomized controlled trial.A total of 174 pregnant women with gestational diabetes mellitus(GDM)who underwent routine prenatal examination in Suqian First People's Hospital from January 2023 to December 2024 were selected as the study group,and 176 healthy pregnant women who underwent routine prenatal examination in the same hospital and during the same period were selected as the control group.The general information of the two groups and their blood glucose control levels at the 24th,28th,30th,32nd,34th and 36th weeks of gestation[fasting plasma glucose(FPG),1 hour postprandial plasma glucose(1 h PG),2 hours postprandial plasma glucose(2 h PG),and glucose time in range(TIR)]were compared.The levels of s-AGEs in two groups at the 24th,28th,30th,32nd,34th and 36th weeks of gestation were compared.Pearson correlation analysis was used to explore the correlation between s-AGEs and blood glucose control level.Receiver operating characteristic(ROC)curves were used to analyze the specific critical value and predictive value of s-AGEs levels on the blood glucose control effect of GDM patients. Results:There were no significant differences in general characteristics between the two groups(P＞0.05).The FPG,1 h PG,2 h PG and s-AGEs levels in the study group were higher than those in the control group at the 24th,28th,30th,32nd,34th and 36th weeks of gestation,and the TIR were lower than those in the control group(P all＜0.05).The s-AGEs level in the study group increased with the increase of gestational weeks,and among them,the differences between the 24th week and the 28th week of gestation,the 30th week and the 32nd week of gestation,and the 34th week and the 36th week of gestation were statistically significant(P＜0.05).Among the study group,the s-AGEs level in patients whose blood glucose control did not meet the standard increased with the increase of gestational weeks,and the differences were statistically significant(P＜0.05),and were higher than those whose blood glucose control reached the standard at the 24th,28th,30th,32nd,34th and 36th weeks of gestation(P＜0.05).The Pearson correlation analysis results showed that the s-AGEs levels in GDM patients at the 24th,28th,30th,32nd,34th and 36th weeks of gestation were positively correlated with FPG,1 h PG,and 2 h PG respectively,and negatively correlated with TIR(P all＜0.05).The ROC analysis results showed that the critical values for predicting the blood glucose control effect in GDM patients based on s-AGEs values at the 24th,28th,30th,32nd,34th and 36th weeks of gestation were 8.60 U/mg,8.74 U/mg,8.88 U/mg,8.95 U/mg,9.34 U/mg and 9.57 U/mg,respectively.The area under the ROC curve(AUC)of blood glucose control effect in GDM patients predicted by s-AGEs levels at each gestational week was higher than those predicted separately(P＜0.05). Conclusions:Compared to healthy pregnant women,the s-AGEs levels of GDM patients at the 24th,28th,30th,32nd,34th and 36th weeks of gestation were all increased,and the s-AGEs levels were related to the patient's blood glucose control level.The combined detection of s-AGEs levels at the above gestational weeks has a high predictive value for the blood glucose control effect in GDM patients.关键词
晚期糖基化终产物/妊娠期糖尿病/血糖控制/临界值Key words
Advanced glycation end products/Gestational diabetes mellitus/Blood glucose control/Critical value分类
医药卫生引用本文复制引用
黄静,赵雪飘,杜娟..唾液晚期糖基化终产物用于无创监测妊娠期糖尿病血糖控制:妊娠特异性临界值体系建立[J].生殖医学杂志,2026,35(1):64-70,7.基金项目
宿迁市第一人民医院科研专项(SY202210) （SY202210）
