新医学2026，Vol.57Issue(1)：80-90,11.DOI:10.12464/j.issn.0253-9802.2025-0261
最小临床重要差值在支气管哮喘疗效测评中的应用与思考
Application and considerations of minimal clinically important difference in efficacy assessment of bronchial asthma
摘要
Abstract
Bronchial asthma,a significant chronic condition,poses a substantial threat to global public health,with a rising number of clinical studies dedicated to understanding this disease.In the analysis of the outcomes of these studies,it is crucial to consider not just statistical significance but also the clinical relevance of the findings.The concept of the minimal clinically important difference(MCID)offers a valuable framework for assessing the clinical relevance of research findings,particularly in the context of asthma-related scales and metrics.It is a pivotal component in the clinical application and interpretation of these tools.Despite the ongoing advancement of localized asthma scale research in China,a notable gap still exists in MCID studies.The methodologies employed in this area are yet to reach a state of maturity,indicating a need for further development and refinement.Consequently,in this article,pertinent literature on the establishment of MCID in the efficacy assessment of bronchial asthma at home and abroad was reviewed,and the research findings were systematically compiled,aiming to analyze and summarize the current application of MCID in the efficacy evaluation of bronchial asthma,offer a theoretical framework that expedites the regional validation of pertinent MCID values within clinical trials for bronchial asthma,while also establish regional efficacy assessment instruments.Concurrently,it will lay a quantitative benchmark and foundation for future clinical research on bronchial asthma.关键词
支气管哮喘/最小临床重要差值/临床疗效/测评工具Key words
Bronchial asthma/Minimal clinically important difference/Clinical efficacy/Assessment tool引用本文复制引用
李明昊,王明航,蒋先伟,李慧茹,王高明,董晓升..最小临床重要差值在支气管哮喘疗效测评中的应用与思考[J].新医学,2026,57(1):80-90,11.基金项目
国家重点研发计划(2023YFC3502602) （2023YFC3502602）
国家科技重大专项课题(2024ZD0522902) （2024ZD0522902）
国家自然科学基金(82474483)、河南省中医药科研专项课题(2025ZY1002) （82474483）
河南省高校科技创新团队支持计划(23IRTSTHN027) （23IRTSTHN027）
