新医学2026，Vol.57Issue(1)：91-99,9.DOI:10.12464/j.issn.0253-9802.2025-0133
免疫应答调控高血压炎症微环境的分子机制
Molecular mechanisms of immune response regulating hypertensive inflammatory microenvironment
摘要
Abstract
Persistence of chronic low-grade inflammation is a key driver of hypertension.Molecular mechanisms such as complement molecules and inflammatory factor disorders damaging blood vessels,neuro-immune cell interactions,and immune response dysregulation aggravating target organ inflammation synergistically break the homeostasis of the inflammatory microenvironment of hypertension.The brain-gut axis mechanism is a new hotspot of hypertension inflammation.Gut microbiota affects the immune response in vivo through short-chain fatty acids(SCFAs)/trimethylamine oxide(TMAO),inducing inflammation and affecting blood pressure.In this article,by integrating the results of multi-dimensional research,new research,new progress and new targets in the direction of hypertension immunity were discussed,providing a new theoretical basis for in-depth understanding of the immunoregulation of hypertension.关键词
高血压/免疫应答/免疫细胞/炎症损伤/肠道菌群Key words
Hypertension/Immune response/Immune cells/Inflammatory damage/Gut microbiota引用本文复制引用
陶玙璠,袁有才..免疫应答调控高血压炎症微环境的分子机制[J].新医学,2026,57(1):91-99,9.基金项目
陕西省自然科学基础研究计划项目(2022JM-470,2021JM-483) （2022JM-470,2021JM-483）
咸阳市中医药科研项目(2023-113-1) （2023-113-1）
咸阳市科学技术局项目(2024-36-87) （2024-36-87）
