现代医药卫生2026，Vol.42Issue(1)：20-26,7.DOI:10.3969/j.issn.1009-5519.2026.01.004
血液炎症标志物、凝血功能指标及肿瘤标志物联合检测在结直肠癌中的临床价值研究
The clinical value of combined detection of blood inflammatory markers,coagulation function indicators and tumor markers in colorectal cancer
摘要
Abstract
Objective To investigate the clinical value of blood inflammatory markers[neutrophil/lym-phocyte ratio(NLR),platelet/lymphocyte ratio(PLR)],coagulation function indicators[fibrinogen(FIB),D-dimer(D-D)]and tumor markers[carcinoembryonic antigen(CEA),carbohydrate antigen 199(CA199)]in the diagnosis and treatment of colorectal cancer(CRC).Analyze the value in the periodization.Methods A to-tal of 317 patients with CRC diagnosed People's Hospital of Changshou District from January 2023 to June 2024(CRC group)and 317 patients with colorectal polyps during the same period(polyp group)were includ-ed.Differences in the levels of NLR,PLR,FIB,D-D,CEA,and CA199 were compared between the two groups;analyze the relationship between the above indexes and different TNM pathologic and clinical stages(Ⅰ,Ⅱ,Ⅲ,Ⅳ),and evaluate the differences in the indexes between patients with early-stage(T1,I)CRC pa-tients and polyp patients.A joint diagnostic model was constructed by correlation analysis and logistic regres-sion.Results The levels of NLR,PLR,FIB,D-D,CEA,and CA199 were significantly higher in the CRC group than in the polyp group(P<0.05).Compared with stage T1,the levels of NLR,PLR,FIB,D-D,CEA,and CA199 were significantly higher in patients with stage T2,T3,and T4(P<0.05).The levels of NLR,FIB,D-D,CEA and CA199 in patients with lymph node metastasis were significantly higher than those in patients without lymph node metastasis,and the differences were statistically significant(P<0.05).Compared with stage M0,the levels of NLR,PLR,FIB,D-D,CEA,and CA199 in patients in stage M1 were significantly in-creased,and the differences were statistically significant(P<0.05).The later the clinical stage of the pa-tients,the higher the levels of NLR,PLR,FIB,D-D,CEA and CA199 in the serum.The levels of NLR,D-D,CEA and CA199 in stages Ⅲ and Ⅳ were significantly higher than those in stages Ⅰ and Ⅱ.The levels of NLR,PLR,FIB,D-D,CEA and CA199 in stage Ⅳ were significantly increased compared with those in stageⅠ,and the differences were statistically significant(P<0.05).In early stage CRC(stage T1 and stage Ⅰ),the levels of NLR,FIB,D-D,and CEA in stage T1 and the levels of FIB,D-D,and CEA in stage Ⅰ were signif-icantly higher than those in the polyp group,and the differences were statistically significant(P<0.05).In patients with CRC,the levels of NLR,FIB,and D-D were positively correlated with CEA(r=0.322,0.321 and 0.316,P<0.05),and D-D was positively correlated with CA199(r=0.382,P<0.05).The AUC of the combined diagnosis of early CRC by FIB+D-D+CEA+CA199 was 0.819(P<0.001).Conclusion Blood in-flammatory indicators,coagulation indicators and tumor markers are closely related to the progression and me-tastasis of CRC.The combined detection of multiple indicators can enhance the efficiency of early diagnosis and provide non-invasive auxiliary basis for the staging assessment and prognosis management of CRC.关键词
结直肠癌/血液炎症标志物/凝血功能指标/肿瘤标志物/诊断/病理分期Key words
Colorectal cancer/Blood inflammatory markers/Coagulation function indicators/Tumor markers/Diagnosis/Pathologic stage分类
医药卫生引用本文复制引用
贺中江,代涛,粟玉凤,聂珂..血液炎症标志物、凝血功能指标及肿瘤标志物联合检测在结直肠癌中的临床价值研究[J].现代医药卫生,2026,42(1):20-26,7.基金项目
重庆市卫生健康委医学科研项目(2025WSJK102) （2025WSJK102）
重庆医药高等专科学校科研项目(ygz2024113). （ygz2024113）
