现代医药卫生2026，Vol.42Issue(1)：153-158,162,7.DOI:10.3969/j.issn.1009-5519.2026.01.029
维生素D在脓毒症中的作用及临床研究进展
The role of vitamin D in sepsis and its clinical research progress
摘要
Abstract
Sepsis is a systemic inflammatory response syndrome caused by infection,and immune disor-ders play a key role in its pathogenesis.In recent years,studies have found that vitamin D not only regulates calcium and phosphorus metabolism,but also has obvious Immunomodulation and anti-infection functions.This article reviews the potential mechanisms of vitamin D in sepsis,including its regulation of innate and a-daptive immunity,anti-inflammatory and promotion of antimicrobial peptide expression,and protective effects on related organ damage.A number of clinical studies have shown that vitamin D deficiency is closely related to the severity and mortality of sepsis,and vitamin D supplementation may improve the prognosis of patients.关键词
维生素D/脓毒症/免疫调节/抗感染/综述Key words
Vitamin D/Sepsis/Immunomodulation/Anti-infection/Review分类
医药卫生引用本文复制引用
张洁,郝东..维生素D在脓毒症中的作用及临床研究进展[J].现代医药卫生,2026,42(1):153-158,162,7.基金项目
山东省济宁市科技计划项目(ZR2021QH105). （ZR2021QH105）
