现代医药卫生2026，Vol.42Issue(1)：163-168,172,7.DOI:10.3969/j.issn.1009-5519.2026.01.031
电压门控钙通道在精神分裂症发病和治疗中的作用
The role of voltage-gated calcium channels in pathogenesis and treatment of schizophrenia
摘要
Abstract
Schizophrenia is a chronic mental disorder that causes psychotic symptoms by affecting early brain development,such as hallucinations,delusions and confusion,and motivational and cognitive dysfunc-tion.Voltage-gated calcium channels are crucial ion channels on the cell membrane,which can regulate calcium ion flow and participate in neuronal excitation and signal transmission and early brain development.Through various mechanisms,including modulation of neurotransmitter release,influence on synaptic plasticity,regula-tion of neuronal excitability and neural network activity,as well as effects on gene expression,Voltage-gated calcium channels play a vital role in maintaining and regulating cognitive functions.Voltage-gated calcium channels comprise multiple subunits and are categorized into high-voltage-activated and low-voltage-activated types.Polymorphisms and expression variations in related genes are associated with schizophrenia,while epi-genetic modifications such as methylation,histone modifications,and non-coding RNAs play significant roles in its pathogenesis.In the treatment of schizophrenia,more selective calcium channel blockers are regarded as a superior therapeutic strategy.This review aims to explore the role of voltage-gated calcium channels in the pathogenesis and treatment of schizophrenia and to provide ideas for the research of etiological mechanisms and treatment of schizophrenia.关键词
精神分裂症/电压门控钙离子通道/遗传多态性/表观遗传修饰Key words
Schizophrenia/Voltage-gated calcium channels/Genetic polymorphism/Epigenetic modification分类
医药卫生引用本文复制引用
魏姿雨,张天祥,王靖涵,王燕龙,刘明慧..电压门控钙通道在精神分裂症发病和治疗中的作用[J].现代医药卫生,2026,42(1):163-168,172,7.基金项目
贺林院士新医学临床转化工作站科研基金项目(JYHL2021MS15) （JYHL2021MS15）
大学生创新创业训练计划项目(CX2025088). （CX2025088）
