现代医药卫生2026，Vol.42Issue(1)：173-182,188,11.DOI:10.3969/j.issn.1009-5519.2026.01.033
IgA肾病肾脏纤维化研究进展
Research progress of renal fibrosis in IgA nephropathy
宋佳蓉 1李毅夫2
作者信息
- 1. 中南大学湘雅二医院肾内科,湖南 长沙 410011
- 2. 中南大学湘雅二医院医学实验研究中心,湖南 长沙 410011
- 折叠
摘要
Abstract
Immunoglobulin A(IgA)nephropathy(IgAN)initiated by abnormal glycosylated IgA1 im-mune complex deposition in mesangial region,which triggers extracellular matrix remodeling by activating complement and inflammatory reaction,thus forming the fibrosis process of glomerulosclerosis,interstitial fi-brosis and vascular disease.Genetic susceptibility cooperates with mucosal immune imbalance,flora imbalance and metabolic disorder to promote mesangial cell activation and podocyte damage,and build a fibrogenic mi-croenvironment.Tubular atrophy/interstitial fibrosis(T score)in the Oxford classification serves as a critical histological marker for predicting progression to end-stage renal disease.At present,the diagnosis depends on renal biopsy,but non-invasive detection techniques,such as liquid biopsy(MicroRNA,etc.),show potential because of their high specificity and accessibility.The treatment strategy tends to be multi-target combined in-tervention,but it is limited by the lack of biomarker verification and dynamic monitoring means.In the future,it is necessary to break through the bottleneck of accurate typing,integrate omics technology to develop non-invasive markers verified by tissues,build an individualized treatment system based on molecular subtyping and facilitate the full control of the fibrotic process.关键词
免疫球蛋白A肾病/肾脏纤维化/发病机制/生物标志物/治疗/综述Key words
Immunoglobulin A nephropathy/Renal fibrosis/Pathogenesis/Biomarkers/Thera-py/Review分类
医药卫生引用本文复制引用
宋佳蓉,李毅夫..IgA肾病肾脏纤维化研究进展[J].现代医药卫生,2026,42(1):173-182,188,11.
