医学信息2026，Vol.39Issue(1)：27-31,5.DOI:10.3969/j.issn.1006-1959.2026.01.004
SOX13生物学功能及在癌症发生中作用机理的研究进展
Research Progress on the Biological Function of SOX13 and its Mechanism in Cancer Occurrence
摘要
Abstract
The SOX family consists of 20 genes,encoding transcription factors with highly conserved high mobility group(HMG)box DNA-binding domains similar to the sex-determining region Y(Sry)protein.These SOX proteins play crucial roles in transcriptional regulation,acting as both positive and negative regulators and exerting their functions through diverse mechanisms.SOX13 is one member of the SOX family,located on chromosome 1q32.SOX13 plays a vital role in biological processes,especially in chondrogenesis,neurogenesis,limb development,tumors and metabolic diseases.This review summarizes the structure and function of SOX13,as well as the latest progress in the occurrence of cancer diseases,in order to help disease diagnosis and clinical treatment.关键词
SOX13/转录因子/癌症/发病机制Key words
SOX13/Transcription factor/Cancer/Pathogenic mechanism分类
医药卫生引用本文复制引用
雷霖,周伟晔,钱玥,张伟..SOX13生物学功能及在癌症发生中作用机理的研究进展[J].医学信息,2026,39(1):27-31,5.基金项目
1.贵州省卫生健康委科学技术基金项目(编号:gzwkj2022-518) （编号:gzwkj2022-518）
2.贵州护理职业技术学院基金项目(编号:gzhlyj2021-02、gzhlyj2025-04) （编号:gzhlyj2021-02、gzhlyj2025-04）
