医学信息2026，Vol.39Issue(1)：40-44,5.DOI:10.3969/j.issn.1006-1959.2026.01.006
血脂代谢水平与痴呆分型因果关系的孟德尔随机化分析
Mendelian Randomization Analysis of the Causal Relationship Between Blood Lipid Metabolism Level and Dementia Classification
摘要
Abstract
Objective To explore the causal relationship between lipid metabolism and dementia by two-sample Mendelian randomization(MR)method.Methods MR analysis was performed using inverse variance weighting(IVW),weighted median method,MR-Egger regression and weighted model.OR value and 95%CI were used to evaluate whether there was a correlation between common blood lipid indexes[total cholesterol(TC),triglyceride(TG),apolipoprotein A(ApoA),apolipoprotein B(ApoB),low-density lipoprotein(LDL),high-density lipoprotein(HDL)]and Alzheimer's disease dementia(AD)and vascular dementia(VAD).Results MR analysis showed that LDL had a positive causal relationship with AD,OR=1.2460(95%CI:1.0367-1.4977,P=0.0191).There was no correlation between other blood lipid indexes and AD and VAD(P>0.05).Conclusion Based on the analysis results,there is a positive causal relationship between LDL and AD.The higher the LDL level,the higher the risk of AD.There is no evidence to support the causal relationship between other blood lipid indexes and AD and VAD.关键词
血脂/痴呆/全基因组关联研究/孟德尔随机化/单核苷酸多样性Key words
Blood lipid/Dementia/Genome-wide association study/Mendelian randomization/Single nucleotide diversity分类
医药卫生引用本文复制引用
查芸璐,王小云,王博,吴慧敏..血脂代谢水平与痴呆分型因果关系的孟德尔随机化分析[J].医学信息,2026,39(1):40-44,5.基金项目
武汉市卫生健康委员会预防医学专项(编号:WY22B10) （编号:WY22B10）
