针刺研究2026，Vol.51Issue(1)：122-129,8.DOI:10.13702/j.1000-0607.20240987
热敏灸辅助肿瘤化疗减毒增效的临床研究
Clinical study on heat-sensitive moxibustion for reducing toxicity and enhancing efficacy in adjuvant tumor chemotherapy
摘要
Abstract
Objective To observe the clinical efficacy of heat-sensitive moxibustion in reducing toxicity and enhancing efficacy in cancer patients undergoing chemotherapy,and to provide a scientific basis for its application and promotion in cancer rehabilitation.Methods A total of 150 malignant tumor patients were selected and randomly divided into a control group(75 cases,with 25 dropouts)and an experimental group(75 cases,with 21 dropouts).The control group received conventional chemotherapy and pharmacological treatment,while the experimental group received additional heat-sensitive moxibustion treatment,which administered once daily for 1 week before and after each chemotherapy session,for 4 consecutive chemotherapy cycles.Evaluation indicators included the incidence of adverse reactions,anorexia/cachexia scale(A/CS-12),nausea and vomiting grading,white blood cell count,platelet count,hemoglobin level,bone marrow suppression grade,and response evaluation criteria in solid tumors(RECIST 1.1).Data were collected before and after each chemotherapy session and statistically analyzed.Results Compared with pre-chemotherapy levels,as the number of chemotherapy sessions was increased,A/CS-12 scores were decreased in both groups(P<0.01),while the incidence of nausea and vomiting increased(P<0.01),the white blood cell count,platelet count,and hemoglobin levels were also decreased(P<0.01).Intergroup comparisons showed that the experimental group had a lower incidence of adverse reactions after each chemotherapy session(P<0.05,P<0.01),higher A/CS-12 scores(P<0.01),and lower rates of nausea and vomiting and bone marrow suppression(P<0.05,P<0.01)than the control group.Hematological analysis indicated that the experimental group had higher white blood cell counts and hemoglobin levels before the 2nd to 4th chemotherapy sessions(P<0.05,P<0.01),and higher platelet counts before the 3rd and 4th sessions(P<0.01).RECIST evolution result showed that the experimental group had an efficacy rate of 50.00%(27/54),which was higher(P<0.05)than that(28.00%[14/50])of the control group.Conclusion Heat-sensitive moxibustion can reduce the incidence of chemotherapy-induced adverse reactions,alleviate gastrointestinal discomfort and bone marrow suppression,improve chemotherapy efficacy.It is worthy of clinical promotion and application.关键词
热敏灸/恶性肿瘤/化疗/减毒增效Key words
Heat-sensitive moxibustion/Malignant tumor/Chemotherapy/Toxicity reduction and efficacy enhancement引用本文复制引用
余婷,柳华伟,刘祖琴,陈日新,谢丁一..热敏灸辅助肿瘤化疗减毒增效的临床研究[J].针刺研究,2026,51(1):122-129,8.基金项目
国家重点基础研究发展计划973项目(No.2015CB554503) （No.2015CB554503）
江西省重大科技研发专项(No.20232ACG01006) （No.20232ACG01006）
江西中医药大学校级科技创新团队发展计划项目(No.CXTD22010) （No.CXTD22010）
江西省2022年度研究生创新专项项目(No.YC2022-B190) （No.YC2022-B190）
山东省中医药科技项目(No.2021M042、Q-2022044) （No.2021M042、Q-2022044）
