空军军医大学学报2026，Vol.47Issue(1)：46-50,5.DOI:10.13276/j.issn.2097-1656.2026.01.007
多自由度四臂动物离心机的研制及在家兔推拉效应模拟中的应用
Development of a multi-degree-of-freedom four-arm animal centrifuge and its application in simulating the push-pull effect in rabbits
摘要
Abstract
Objective To design and develop a multi-degree-of-freedom four-arm animal centrifuge for simulating the push-pull effect(PPE)and evaluating its physiological impacts.Methods The centrifuge consisted of a drive and support system,a four-arm rotating system,an animal loading platform,a control system,and a physiological monitoring system.Eight rabbits were subjected to two types of acceleration exposures:all animals first underwent+Gz exposure(+5 Gz for 20 s)as a control;after full physiological recovery,they were then exposed to PPE(-1 Gz for 10 s→+4 Gz for 20 s).Arterial blood pressure was monitored in real time using pressure sensors,and respiratory changes were recorded using tension sensors.Results PPE was successfully simulated in the rabbit model using this centrifuge.Compared with the+Gz exposure group,the PPE group showed a significantly greater decrease in mean arterial pressure at heart level(P<0.01).Both exposure modes caused a significant increase in respiratory rate(P<0.01).Conclusion A multi-degree-of-freedom four-arm animal centrifuge is successfully constructed,which can effectively simulate complex aviation acceleration environments.Using this device,the effects of PPE on cardiovascular and respiratory functions in rabbits are preliminarily revealed,providing an experimental basis and a technical platform for further investigation into physiological responses and injury mechanisms under high-G environments.关键词
多自由度/四臂动物离心机/持续性正加速度/推拉效应/高过载/心血管系统/心水平动脉压/呼吸频率Key words
multi-degree-of-freedom/four-arm animal centrifuge/continuous positive acceleration/push-pull effect/high G/cardiovascular system/heart-level arterial blood pressure/respiratory rate分类
医药卫生引用本文复制引用
谢暄,张舒,延姪君,张俊飞,周好斌,石菲,高峰,胡泽兵,高原,张茹..多自由度四臂动物离心机的研制及在家兔推拉效应模拟中的应用[J].空军军医大学学报,2026,47(1):46-50,5.基金项目
国家自然科学基金面上项目(32271227) （32271227）
