中风与神经疾病杂志2026，Vol.43Issue(1)：10-14,5.DOI:10.19845/j.cnki.zfysjjbzz.2026.0002
季节性血压变异与不同严重程度脑小血管病总负荷评分的相关性分析
Correlation between seasonal blood pressure variability and total burden score of cerebral small vessel disease with different severities
摘要
Abstract
Objective To investigate the correlation between seasonal blood pressure(BP)variability and total burden score of cerebral small vessel disease(CSVD)with different severities.Methods The patients with CSVD who were consecu-tively admitted were enrolled,and according to the total burden score based on head MRI,they were divided into control group(CSVD 0 points),mild group(CSVD 1-2 points),and moderate-to-severe group(CSVD 3-4 points).General information was collected from all patients,as well as 24-hour ambulatory blood pressure monitoring(ABPM)during warm and cold seasons.The correlation between ABPM parameters in different seasons and the imaging burden of different severities of CSVD was analyzed.Results A total of 145 patients were enrolled,with 29 patients in the control group,64 in the mild group,and 52 in the moderate-to-severe group.Compared with the control group,the mild group and the moderate-to-severe group had significantly higher age(F=9.721,P=0.001),24-hour systolic blood pressure(SBP)in hot season(F=6.572,P=0.002),daytime SBP in hot season(F=6.460,P=0.002),daytime diastolic blood pressure(DBP)in hot season(F=5.802,P=0.004),nighttime SBP in hot season(F=8.508,P<0.001).Compared with the control group,the moderate-to-severe group had significantly higher levels of 24-hour DBP in hot season(F=4.564,P=0.012),nighttime DBP in hot season(F=6.294,P=0.002),24-hour SBP in cold season(F=7.012,P=0.001),24-hour DBP in cold season(F=4.527,P=0.012),daytime SBP in cold season(F=5.708,P=0.004),daytime DBP in cold season(F=3.138,P=0.046),nighttime SBP in cold season(F=9.154,P<0.001),and night-time DBP in cold season(F=8.006,P=0.001).Compared with the control group,the mild group and the moderate-to-severe group had a significantly higher proportion of patients with abnormal BP circadian rhythm in hot season(χ2=13.059,P=0.001)and cold season(χ2=10.091,P=0.006).The ordinal logistic regression analysis showed that age(OR=1.147,95%CI 1.084-1.214)was an independent risk factor for CSVD,and compared with the patients with dipper-type blood pressure in hot season,the patients with non-dipper blood pressure pattern had a risk of CSVD increased by 13.282 times(OR=13.282,95%CI 2.379-74.159),while those with reverse-dipper blood pressure pattern had a risk of CSVD increased by 25.569 times(OR=25.569,95%CI 3.061-213.551).Conclusion The imaging burden score of CSVD increases with the increase in age and the proportion of abnormal circadian blood pressure pattern in hot season,and both age and abnormal circadian blood pressure pattern in hot season are independent risk factors for the imaging bur-den of CSVD.关键词
脑小血管病/动态血压/血压变异性/危险因素/磁共振成像Key words
Cerebral small vessel disease/Ambulatory blood pressure/Blood pressure variability/Risk fac-tors/Magnetic resonance imaging分类
医药卫生引用本文复制引用
刘欣,王丽娟,刘荧,崔明愚,李皓,魏欣..季节性血压变异与不同严重程度脑小血管病总负荷评分的相关性分析[J].中风与神经疾病杂志,2026,43(1):10-14,5.基金项目
首都卫生发展科研专项(首发2022-3-7041) （首发2022-3-7041）
