中风与神经疾病杂志2026，Vol.43Issue(1)：35-39,5.DOI:10.19845/j.cnki.zfysjjbzz.2026.0006
作业疗法在脑小血管病患者认知功能损伤中的应用价值
Application value of occupational therapy in cognitive impairment in patients with cerebral small vessel disease
摘要
Abstract
Objective To investigate the application value of occupational therapy in cognitive impairment in pa-tients with cerebral small vessel disease.Methods A total of 84 patients with cerebral small vessel disease who were ad-mitted to our hospital from April 2021 to September 2022 and were found to have cognitive impairment were enrolled as subjects,and they were randomly divided into observation group and control group using a random number table,with 42 patients in each group.The patients in the control group received conventional Western medicine treatment,while those in the observation group received occupational therapy in addition to the treatment in the control group.After 8 weeks of con-tinuous treatment,the two groups were compared in terms of treatment outcome,Mini-Mental State Examination(MMSE)score,Montreal Cognitive Assessment(MoCA)score,brain-derived neurotrophic factor(BDNF),high-sensitivity C reac-tive protein(hs-CRP),homocysteine(Hcy),and cerebral blood perfusion parameters.Results The treatment group had a higher overall response rate than the control group(95.24%vs 73.81%,P<0.05).After treatment,the observa-tion group had significantly higher MMSE,MoCA,and MBI scores than the control group(P<0.05).Compared with the control group,the observation group had a significantly lower MTT and significantly higher CBV and CBF(P<0.05).Compared with the control group,the observation group had a significantly higher level of BDNF and significantly lower levels of hs-CRP and Hcy(P<0.05).Conclusion Occupational therapy has a marked clinical effect in patients with cerebral small vessel disease and cognitive impairment and can effectively improve cognitive function and cerebral blood perfusion,upregulate the level of BDNF,and reduce the expression of hs-CRP and Hcy.It is of great significance for improving the quality of life and prognosis of patients.关键词
脑小血管病/认知功能损伤/作业疗法/脑血流灌注/超敏C反应蛋白/同型半胱氨酸Key words
Cerebral small vessel disease/Cognitive impairment/Occupational therapy/Cerebral blood perfusion/High-sensitivity C reactive protein/Homocysteine分类
医药卫生引用本文复制引用
王曼,杨青松,彭辉..作业疗法在脑小血管病患者认知功能损伤中的应用价值[J].中风与神经疾病杂志,2026,43(1):35-39,5.基金项目
2020 年度河南省医学科技攻关计划联合共建项目(LHGJ20200926) （LHGJ20200926）
