中风与神经疾病杂志2026，Vol.43Issue(1)：40-46,7.DOI:10.19845/j.cnki.zfysjjbzz.2026.0007
脑小血管病患者运动认知风险综合征的神经影像学研究
A neuroimaging study of motoric cognitive risk syndrome in patients with cerebral small vessel disease
摘要
Abstract
Objective To investigate the association between motoric cognitive risk syndrome(MCR)and neuroim-aging markers in patients with cerebral small vessel disease(CSVD),to assess the imaging markers associated with MCR,and to compare the differences in imaging markers between MCR and mild cognitive impairment(MCI).Methods A ret-rospective study was conducted among 187 patients with CSVD who were admitted to Department of Neurology,Hebei Medical University Third Hospital,from April 2023 to November 2024,and they were divided into groups based on whether they were diagnosed with MCR or MCI.Clinical and imaging data were collected,and the univariate and multi-variate logistic regression analyses were used to investigate the imaging features of CSVD patients with MCR.Results Compared with the MCR-negative group,the MCR-positive group had significantly higher BMI,proportion of male patients,and proportion of patients with hypertension,lacunar infarcts,severe white matter hyperintensity(WMH),severe enlarged perivascular space(EPVS)in the basal ganglia,and high CSVD total burden(P<0.05).The multivariate logistic regression analysis showed that the total volume of WMH was an independent risk factor for MCR in CSVD patients(OR=1.038,95%CI 1.003-1.075,P=0.033).Stratification by MCI,MCR showed that compared with the other groups,the MCI+/MCR+group had a significantly higher proportion of patients with hypertension(the MCI-/MCR+group had a higher proportion of patients with hypertension than the MCI+/MCR-group),a significantly higher total volume of WMH,a significantly higher proportion of patients with severe deep brain and paraventricular WMH,and a significantly higher proportion of patients with severe EPVS(P<0.05).Compared with the MCI+/MCR-group,the MCI-/MCR+group had sig-nificantly higher grades(a significantly higher proportion of patients with grade 2 or 3 WMH than the MCI+/MCR-group)and total volume of periventricular and deep WMH(P<0.05).There was no significant difference in CSVD total burden between groups(P>0.05).Conclusion WMH is an independent risk factor for MCR in patients with CSVD.MCR is as-sociated with a larger volume of WMH.This study highlights white matter abnormalities in MCR and the potential of motor function assessment in early risk stratification for dementia.关键词
脑小血管病/运动认知风险综合征/轻度认知障碍/步态障碍/影像学标志物Key words
Cerebral small vessel disease/Motoric cognitive risk syndrome/Mild cognitive im-pairment/Gait disturbance/Imaging markers分类
医药卫生引用本文复制引用
胡晓凯,李文君,贾亚南,刘翠翠,吴玲玲,任慧玲,董玉娟..脑小血管病患者运动认知风险综合征的神经影像学研究[J].中风与神经疾病杂志,2026,43(1):40-46,7.基金项目
2024年度河北省医学科研研究课题计划(20240198) （20240198）
