中国感染控制杂志2026，Vol.25Issue(1)：137-144,8.DOI:10.12138/j.issn.1671-9638.20262417
PPARγ在金黄色葡萄球菌感染中的分子作用机制研究进展
Research progress on the molecular mechanisms of PPARγ in Staphylo-coccus aureus infection
摘要
Abstract
Staphylococcus aureus infection is one of the common clinical infectious diseases.Its clinical treatment encoun-ters significant challenges.Peroxisome proliferator-activated receptor γ(PPARγ),as a member of the nuclear receptor family,has multiple mechanisms in regulating inflammatory response,immune cell function,and skin barrier repair,and plays a key role in Staphylococcus aureus infection.PPARγ can inhibit excessive inflammatory response,reconstruct immune response,and promote epidermal regeneration,thus is expected to be a new target for the treatment of Staphylococcus aureus infection.This review systematically summarizes the molecular network of PPARγ in inflammation regulation,immunoregulation,and barrier repair,aiming to provide theoretical basis for the development of targeted therapy strategies.关键词
金黄色葡萄球菌/过氧化物酶体增殖物激活受体γ/致病机制/免疫调节Key words
Staphylococcus aureus/peroxisome proliferator-activated receptor γ/pathogenic mechanism/immu-noregulation分类
医药卫生引用本文复制引用
闫文通,许森,张轩,潘海邦,梁文萱,王波..PPARγ在金黄色葡萄球菌感染中的分子作用机制研究进展[J].中国感染控制杂志,2026,25(1):137-144,8.基金项目
甘肃省重点人才项目(2025RCXM032) （2025RCXM032）
甘肃省科学技术厅自然科学基金(24JRRA1024) （24JRRA1024）
甘肃省中药药理与毒理学重点实验室开放基金项目(ZDSYS-KJ-2024-008) （ZDSYS-KJ-2024-008）
甘肃省高校教师创新基金项目(2025A-119) （2025A-119）
甘肃省教育厅研究生"创新之星"项目(2025CXZX-948) （2025CXZX-948）
