医疗卫生装备2026，Vol.47Issue(1)：14-20,7.DOI:10.19745/j.1003-8868.2026003
高压脉冲电场消融中电极几何参数与组织介电特性对阻抗测量灵敏度的影响研究
Effects of electrode geometric parameters and tissue dielectric properties on sensitivity of impedance measurements in high-voltage pulsed electric field ablation
摘要
Abstract
Objective To investigate the effects of electrode geometric parameters and tissue dielectric properties on impedance measurement sensitivity during high-voltage pulsed electric field ablation,thereby providing a theoretical basis for selecting electrode pairs for impedance spectrum measurement in this procedure.Methods Firstly,a three-dimensional finite element model was established based on COMSOL Multiphysics 6.2 to simulate the current density field under homogeneous tissue conditions by varying key parameters such as tissue conductivity,relative permittivity,electrode spacing and exposure length.Subsequently,the spatial characteristics of the sensitivity distribution were quantified using a threshold segmentation algorithm,and the sensitivity distribution within the impedance-effective measurement region was analyzed.Finally,the influence of tissue heterogeneity on the sensitivity distribution was systematically investigated by introducing perturbation zones with different conductivity gradients into the model to simulate heterogeneous tissue conditions.Results Variations in the dielectric parameters(σ,εr)of homogeneous tissue showed no significant effects on the distribution of impedance measurement sensitivity.Electrode spacing was positively correlated with the area of the effective impedance measurement region,while measurement sensitivity decreased significantly when the spacing exceeded 4.0 cm;electrode exposure length was positively correlated with the cross-sectional area of the effective impedance measurement region in the longitudinal plane.In heterogeneous tissue,an increase in local conductivity significantly enhanced the impedance measurement sensitivity in that region.Conclusion The quantitative influences of tissue dielectric parameters and electrode geometric parameters on the effective impedance measurement area are revealed during high-voltage pulsed electric field ablation,providing references for selecting electrode pairs for impedance spectrum measurement in irreversible electroporation therapy.[Chinese Medical Equipment Journal,2026,47(1):14-20].关键词
高压脉冲电场消融/阻抗测量灵敏度/阻抗有效测量区域/电极几何参数/组织介电特性Key words
high-voltage pulsed electric field ablation/impedance measurement sensitivity/effective impedance measure-ment area/electrode geometric parameter/tissue dielectric parameter分类
医药卫生引用本文复制引用
宋汝腾,刘本源,李俊瑶,朱明旭,马强,季振宇..高压脉冲电场消融中电极几何参数与组织介电特性对阻抗测量灵敏度的影响研究[J].医疗卫生装备,2026,47(1):14-20,7.基金项目
国家重点研发计划项目(2019YFC0119103) （2019YFC0119103）
