中国美容医学2026，Vol.35Issue(2)：5-9,5.
双层人工真皮修复手足部肌腱及骨外露创面疗效分析
Efficacy Analysis of Double-layer Artificial Dermis in Repairing Hand and Feet Tendon and Bone Exposure Wounds
蔺利剑 1王旭文 1苏伟海 1赵龙刚 1邓凯 1李雯2
作者信息
- 1. 河北中石油中心医院整形手外烧伤科 河北廊坊 065000
- 折叠
摘要
Abstract
Objective To explore the effect of double-layer artificial dermis in repairing wounds with tendon and bone exposure in hands and feet.Methods A total of 80 patients with hand and foot tendon and bone exposure admitted to Hebei China Petroleum Central Hospital from June 2020 to October 2023 were selected as the research objects.According to the random number table method,they were divided into the control group and the observation group,with 40 cases in each group.The control group was treated with skin healing dressing combined with autologous thick skin graft,while the observation group was treated with double-layer artificial dermis combined with autologous thick skin graft.The survival and treatment of skin grafting on the 14th day after operation,the levels of serum inflammatory factors and wound growth factors on the 3rd and 14th day after operation,and the expression of apoptotic genes on the 3rd and 14th day after operation were statistically compared between the two groups.The wound repair aesthetics of the two groups was statistically compared 6 months after operation.Results At 14 days after operation,the survival of skin grafting in the observation group was better than that in the control group(P＜0.05).There was no significant difference in the number of skin grafting and hospital stay between the two groups(P＞0.05).The transplantation interval time in the observation group was longer than that in the control group(P＜0.05).At 14 days after operation,the serum levels of TNF-α and IFN-γ in the two groups were lower than those at 3 days after operation(P＜0.05),but there was no significant difference between the two groups(P＞0.05).At 14 days after operation,the levels of VEGF and TGF-β1 in the two groups were higher than those at 3 days after operation,but those in the observation group were lower than those in the control group(P＜0.05).The levels of p53,Bax,and Caspase-3 in the two groups were decreased,but there was no significant difference between the two groups(P＞0.05).At 6 months after operation,the scores of all aspects and total score of VSS in the observation group were lower than those in the control group(P＜0.05).Conclusion Double-layer artificial dermis could effectively promote the wound healing of patients with tendon and bone exposure in hands and feet,stabilize the inflammatory state in vivo and the expression of wound apoptosis gene,reduce scar formation,improve the aesthetics of wound repair and improve the survival of skin grafting,but it had the disadvantage of long transplant interval.关键词
手足部/肌腱外露/骨外露/创面/双层人工真皮/皮片移植Key words
hand and foot/tendon exposure/bone exposure/wound/double-layer artificial dermis/skin graft分类
医药卫生引用本文复制引用
蔺利剑,王旭文,苏伟海,赵龙刚,邓凯,李雯..双层人工真皮修复手足部肌腱及骨外露创面疗效分析[J].中国美容医学,2026,35(2):5-9,5.
