中国临床药理学杂志2025，Vol.41Issue(21)：3001-3006,6.DOI:10.13699/j.cnki.1001-6821.2025.21.001
2017-2024年北京市某三甲医院鲍曼不动杆菌复合群的检出情况和耐药分布
Detection and antimicrobial resistance distribution of Acinetobacter baumannii complex in a grade A tertiary hospital in Beijing(2017-2024)
摘要
Abstract
Objective To analyze the species distribution and antimicrobial resistance profiles of Acinetobacter baumannii complex(ABC)isolates from a Grade A tertiary hospital in Beijing(2017-2024),providing evidence for clinical microbiological identification and antimicrobial therapy.Methods ABC isolates were collected from the hospital's antimicrobial resistance surveillance network.Species identification was performed by mass sectrometry and susceptibility testing was analyzed using WHONET 5.6.Statistical comparisons of resistance rates were performed with SPSS 26.0(chi-square test).Results Among 2 752 non-repetitive ABC isolates,Acinetobacter baumannii(ABA)accounted for 91.75％,followed by Acinetobacter pittii(APT,6.90％)and Acinetobacter nosocomialis(ANO,1.31％).Sputum and urine were the predominant specimen types,with ABA and APT frequently isolated from bloodstream infections.The resistance profile varied statistically significantly defferences across the bacterial species for all 12 common antimicrobials(all P＜0.05).Among these,ABA demonstrated the highest resistance rates,ANO showed an intermediate profile,and APT was the most susceptible.Specifically,ABA exhibited resistance rates exceeding 80％to β-lactam antibiotics,including piperacillin/tazobactam,ceftazidime,imipenem and meropenem.In contrast,ANO showed resistance rates of 30％-50％,and APT only 10％-30％to the same agents.Resistance profiles between ABA and ANO differed statistically significantly except for trimethoprim-sulfamethoxazole and minocycline(all P＞0.05).The single Acinetobacter calcoaceticus isolate was only resistant to doxycycline and trimethoprim-sulfamethoxazole,while remaining susceptible to all other β-lactam and fluoroquinolone agents tested.Conclusion ABC species exhibit distinct clinical distributions and resistance patterns,emphasizing the need for accurate species identification and ongoing resistance surveillance to guide appropriate empirical therapy.关键词
鲍曼不动杆菌/皮特不动杆菌/医院不动杆菌/准确鉴定/基质辅助激光解吸电离飞行时间质谱/耐药率Key words
Acinetobacter baumannii/Acinetobacter pittii/Acinetobacter nosocomialis/accurate identification/matrix-assisted laser desorption ionization time of flight mass spectrometry/resistance rate分类
医药卫生引用本文复制引用
夏昌宇,周佳,冯汝立,严岩,黄磊..2017-2024年北京市某三甲医院鲍曼不动杆菌复合群的检出情况和耐药分布[J].中国临床药理学杂志,2025,41(21):3001-3006,6.基金项目
中央高水平医院临床科研业务费资助北京大学第一医院跨学科交叉临床研究专项基金资助项目(2023IR46) （2023IR46）
