中国比较医学杂志2025，Vol.35Issue(12)：141-151,11.DOI:10.3969/j.issn.1671-7856.2025.12.015
HIF-1α/VEGF信号通路在缺血性脑卒中的作用及中医药干预研究进展
Role of HIF-1α/VEGF signaling and advances in understanding traditional Chinese medicine interventions in ischemic stroke
摘要
Abstract
Ischemic stroke is one of the most prevalent cerebrovascular diseases.The HIF-1α/VEGF signaling pathway is as a crucial mediator of angiogenesis and has demonstrated bidirectional effects in ischemic stroke treatment through multifaceted mechanisms involving angiogenesis,neurogenesis,oxidative stress,the inflammatory response,and autophagy.Emerging evidence indicates that traditional Chinese medicine can exert therapeutic effects on ischemic stroke by targeting the HIF-1α/VEGF pathway,effectively ameliorating oxidative stress,inflammatory reactions,cellular autophagy,and apoptosis,while promoting vascular regeneration in ischemic regions.Here,we review the dual-phase regulatory mechanisms and functional characteristics of the HIF-1α/VEGF signaling pathway in ischemic stroke pathogenesis and progression.Furthermore,we summarize recent advances in traditional Chinese medicine-based interventions that target this pathway to provide evidence-based theoretical support and clinical references that will help to optimize therapeutic strategies against this debilitating neurological disorder.关键词
缺血性脑卒中/HIF-1α/VEGF信号通路/中医药/作用机制Key words
ischemic stroke/HIF-1α/VEGF signaling pathway/traditional Chinese medicine/mechanism of action分类
医药卫生引用本文复制引用
王森雨,刘向哲,马驰远,冉春龙..HIF-1α/VEGF信号通路在缺血性脑卒中的作用及中医药干预研究进展[J].中国比较医学杂志,2025,35(12):141-151,11.基金项目
河南省科技攻关项目(242102311277) （242102311277）
河南省中医药科研专项课题(2024ZXZX1017) （2024ZXZX1017）
河南省"双一流"创建学科中医学科研专项课题(HSRP-DFCTCM-2023-2-18) （HSRP-DFCTCM-2023-2-18）
河南省中医药传承与创新人才工程(仲景工程)中医药学科领军人才(豫卫中医函[2021]8号). （仲景工程）
