中国临床药理学杂志2025，Vol.41Issue(21)：3038-3042,5.DOI:10.13699/j.cnki.1001-6821.2025.21.007
同时携带vanA和vanM耐药基因屎肠球菌流行现状研究
Epidemiological landscape of Enterococcus faecium co-harboring both vanA and vanM resistance genes
苏博 1郑波1
作者信息
- 1. 北京大学第一医院临床药理研究所,北京 100034
- 折叠
摘要
Abstract
Objective To analyze the drug resistance phenotypes and genotypes of 2 307 Enterococcus faecium strains collected from 2011 to 2024.Methods The antimicrobial susceptibility testing of the strains was performed using the broth microdilution method,followed by genomic DNA extraction from the strains and polymerase chain reaction(PCR)amplification for screening of resistance genes.Results From 2011 to 2012,the detection rate of vancomycin-resistant Enterococcus faecium was 1.67％,and the detection rate of vanM gene-positive vancomycin-susceptible strains was 0.34％.In contrast,from 2023 to 2024,the detection rate of vancomycin-resistant Enterococcus faecium increased to 5.11％,while the detection rate of vanM gene-positive vancomycin-susceptible strains reached as high as 4.75％.Additionally,22 Enterococcus faecium strains co-harboring both vanA and vanM resistance genes were identified during the period from 2021 to 2024.Conclusion The detection rate of the vanM resistance gene in Enterococcus faecium has increased year by year,and its horizontal transfer may have contributed to the increased prevalence of Enterococcus faecium co-harboring both vanA and vanM resistance genes in recent years.关键词
万古霉素/屎肠球菌/vanA基因/vanM基因Key words
vancomycin/Enterococcus faecium/vanA gene/vanM gene分类
医药卫生引用本文复制引用
苏博,郑波..同时携带vanA和vanM耐药基因屎肠球菌流行现状研究[J].中国临床药理学杂志,2025,41(21):3038-3042,5.
