疑难病杂志2026，Vol.25Issue(1)：25-30,6.DOI:10.3969/j.issn.1671-6450.2026.01.005
慢性心力衰竭患者血清COL1A1、CCN1水平及其与预后的相关性
Serum COL1A1 and CCN1 levels in patients with chronic heart failure and the association with prognosis
摘要
Abstract
Objective To investigate the expression of serum type Ⅰ collagen α1 chain(COL1A1)and cellular communication network factor 1(CCN1)in patients with chronic heart failure(CHF)and their correlation with prognosis.Me-thods 158 patients with CHF(CHF group)and 79 healthy subjects(control group)who were treated in the Second Affiliated Hospital of Nanjing Medical University from January 2022 to August 2024 were prospectively selected according to the ratio of 2∶1.The levels of serum COL1A1 and CCN1 were detected by enzyme-linked immunosorbent assay.According to the risk stratification,CHF patients were divided into low-risk CHF group(52 cases),medium-risk CHF group(60 cases)and high-risk CHF group(46 cases).The correlation between serum COL1A1,CCN1 levels and risk stratification in CHF patients was analyzed by Spearman rank correlation.CHF patients were divided into poor subgroup and good subgroup according to the 6-month prognosis.The prognostic factors of CHF patients and the predictive efficacy of serum COL1A1 and CCN1 levels were analyzed.Results Compared with the control group,the levels of serum COL1A1 and CCN1 in the CHF group were increased(t/P=24.185/＜0.001,18.129/＜0.001);The levels of serum COL1A1 and CCN1 in patients with low-risk CHF,medi-um-risk CHF and high-risk CHF increased in turn(F/P=64.321/＜0.001,63.243/＜0.001);Compared with the good subgroup,the patients in the poor subgroup were older,the proportion of NYHA cardiac function grade Ⅳ was higher,the proportion of high-risk stratification was higher,the level of NT-proBNP was higher,the level of COL1A1 was higher,and the level of CCN1 was higher(x2/t/U/P=3.176/0.002,1165.000/＜0.001,704.000/＜0.001,5.815/＜0.001,6.913/＜0.001,7.267/＜0.001);the levels of serum COL1A1 and CCN1 in CHF patients were positively correlated with risk stratification(rs/P=0.653/＜0.001,0.649/＜0.001);the 6-month poor prognosis rate of 158 CHF patients was 32.91％(52/158);Age increase,NYHA cardiac function grade Ⅳ,high risk stratification,elevated NT-proBNP,elevated COL1A1,and elevated CCN1 were independent risk factors for poor prognosis in CHF patients[OR(95％CI)=1.102(1.026-1.184),9.301(2.221-38.943),7.074(1.352-36.995),1.001(1.001-1.002),1.027(1.010-1.045),1.051(1.023-1.079)];The AUC of serum COL1A1,CCN1 levels and the combination of the two in predicting the poor prognosis of CHF patients were 0.790,0.806 and 0.880,respectively.The AUC of the combi-nation of the two in predicting the poor prognosis of CHF patients was greater than that of the two alone(Z/P=3.002/0.003,2.757/0.006).Conclusion The levels of serum COL1A1 and CCN1 in patients with CHF are increased,which is related to the aggravation of risk stratification and poor prognosis.The combination of the two has a higher predictive efficiency for prognosis.关键词
慢性心力衰竭/Ⅰ型胶原α1链/蜂窝通信网络因子1/危险分层/预后Key words
Chronic heart failure/Type Ⅰ collagen alpha-1 chain/Cellular communication network factor 1/Risk stratification/Prognosis分类
医药卫生引用本文复制引用
张玥,李秀珍,杜新丽,朱嵘..慢性心力衰竭患者血清COL1A1、CCN1水平及其与预后的相关性[J].疑难病杂志,2026,25(1):25-30,6.基金项目
江苏省卫生健康委科研项目(Z2024018) Research Project of Jiangsu Provincial Health Commission(Z2024018) （Z2024018）
