中国药业2026，Vol.35Issue(3)：108-112,5.DOI:10.3969/j.issn.1006-4931.2026.03.021
化瘀通络法通过调控Janus激酶2/信号转导与转录激活因子3信号通路介导的炎性反应治疗慢性萎缩性胃炎临床研究
Clinical Study of Huayu Tongluo Method in the Treatment of Chronic Atrophic Gastritis by Regulating JAK2/STAT3 Signaling Pathway-Mediated Inflammatory Response
摘要
Abstract
Objective To investigate the clinical efficacy of Huayu Tongluo method in the treatment of chronic atrophic gastritis(CAG)by regulating the Janus kinase 2(JAK2)/signal transducer and activators of transcription 3(STAT3)signaling pathway-mediated inflammatory response.Methods A total of 86 patients with CAG admitted to the hospital from April 2022 to April 2024 were selected and divided into the treatment group and the control group by the random number table method,with 43 cases in each group.The patients in the two groups were treated with standard quadruple therapy(amoxicillin+clarithromycin+bismuth+omeprazole),and the patients in the treatment group were treated additionally with the Huayu Tongluo method(modified Huayu Tongluo Formula).Both groups were treated continuously for 14 d.Results The total effective rate in the treatment group was 86.05%,which was significantly higher than 60.47%in the control group(P<0.05).After treatment,the traditional Chinese medicine(TCM)syndrome scores and gastric mucosal pathology scores in the two groups significantly reduced(P<0.05),and those in the treatment group were significantly lower than those in the control group(P<0.05);the levels of serum pepsinogen(PG)Ⅰ,PG Ⅰ/PG Ⅱ,and gastrin 17(G-17)in the two groups significantly increased(P<0.05),while the levels of PG Ⅱin the two groups significantly decreased(P<0.05),and those in the treatment group were significantly better than those in the control group(P<0.05);the relative expression levels of JAK2 mRNA and STAT3 mRNA in gastric mucosal tissue,and the serum levels of interleukin-6 and tumor necrosis factor-α in the two groups significantly reduced(P<0.05),and those in the treatment group were significantly lower than those in the control group(P<0.05).Conclusion Huayu Tongluo method can inhibit the inflammatory damage of gastric mucosa by regulating the JAK2/STAT3 signaling pathway-mediated the inflammatory response,promote the repair and regeneration of gastric mucosa,improve the defense function of gastric mucosa,and thus achieve the purpose of treating CAG.关键词
化瘀通络法/慢性萎缩性胃炎/Janus激酶2/信号转导与转录激活因子3信号通路/炎性反应Key words
Huayu Tongluo method/chronic atrophic gastritis/JAK2/STAT3 signaling pathway/inflammatory response分类
医药卫生引用本文复制引用
陈晓,刘春倩,刘银鸿..化瘀通络法通过调控Janus激酶2/信号转导与转录激活因子3信号通路介导的炎性反应治疗慢性萎缩性胃炎临床研究[J].中国药业,2026,35(3):108-112,5.基金项目
河北省中医药管理局科研计划项目[2025177,2018551]. （）
