中国药业2026，Vol.35Issue(3)：116-120,5.DOI:10.3969/j.issn.1006-4931.2026.03.023
罗哌卡因局部浸润辅助全身麻醉对脊柱手术患者术后疼痛与快速康复的影响
Effect of Ropivacaine Local Infiltration-Assisted General Anesthesia on Postoperative Pain and Enhanced Recovery in Patients Undergoing Spinal Surgery
摘要
Abstract
Objective To investigate the effect of ropivacaine local infiltration-assisted general anesthesia on postoperative pain and enhanced recovery in patients undergoing spinal surgery.Methods A total of 100 patients admitted to the hospital from August 2023 to June 2024 and scheduled to undergo spinal surgery were selected and randomly divided into the control group and the observation group,with 50 cases in each group.The patients in the two groups underwent general anesthesia,the patients in the control group were immediately connected to a patient-controlled intravenous analgesia(PCIA)pump after surgery and received sufentanil for analgesia,while the patients in the observation group received local infiltration of Ropivacaine Hydrochloride Injection around the incision immediately after surgery,and received the same PCIA regimen as in the control group for postoperative analgesia after suturing incision.Results Compared with those in the control group,the degree of incision pain during both active and resting states in the observation group significantly reduced at 4,8,12,24,and 48 h after surgery(P<0.05),the levels of pain-related factors(neuropeptide Y,serotonin,histamine,substance P)and inflammatory factors(tumor necrosis factor-α,interleukin-1β,interleukin-6)in the observation group significantly decreased at 24 and 48 h after surgery(P<0.05),the time for drain removal,first flatus,and assisted ambulation,and the length of hospital stay in the observation group significantly shortened(P<0.05).There were no significant differences in coagulation function(prothrombin time,activated-partial thromboplastin time,fibrinogen)between the two groups at 24 and 48 h after surgery(P>0.05).The incidence rates of adverse reactions and complications in the observation group were 4.00%and 2.00%,which were significantly lower than 18.00%and 14.00%in the control group(P<0.05).Conclusion Ropivacaine local infiltration-assisted general anesthesia can significantly alleviate postoperative pain and inflammatory response in patients undergoing spinal surgery,reduce complications,promote rapid recovery,and has good safety.关键词
罗哌卡因/局部浸润/辅助全身麻醉/脊柱手术/镇痛效果/快速康复/并发症Key words
ropivacaine/local infiltration/assisted general anesthesia/spinal surgery/analgesic effect/enhanced recovery/complication分类
医药卫生引用本文复制引用
张利强,冉丽,叶和,熊洋..罗哌卡因局部浸润辅助全身麻醉对脊柱手术患者术后疼痛与快速康复的影响[J].中国药业,2026,35(3):116-120,5.基金项目
重庆市璧山区科研项目[BSKJ2023015]. （）
