中国中西医结合影像学杂志2026，Vol.24Issue(1)：45-49,5.DOI:10.3969/j.issn.1672-0512.2026.01.009
3D-pCASL技术对大脑中动脉闭塞性脑梗死患者脑血管储备能力及静脉溶栓治疗预后的评估价值
Value of 3D-pCASL technique in assessing vascular reserve capacity and prognosis of intravenous thrombolysis in patients with middle cerebral artery occlusive cerebral infarction
摘要
Abstract
Objective:To investigate the role of three-dimensional pseudo-continuous arterial spin labeling(3D-pCASL)technique in the assessment of vascular reserve capacity and prognosis of intravenous thrombolysis in patients with middle cerebral artery(MCA)occlusive cerebral infarction.Methods:Ninety-eight patients with MCA occlusive cerebral infarction diagnosed by imaging examination were selected as the study subjects,and all patients underwent brain perfusion imaging using the 3D-pCASL technique.The cerebral blood flow(CBF)on the affected side and the healthy side were measured at PLD=1.5,2.5 seconds.Patients were divided into the recanalization group(57 cases)and the non-recanalization group(41 cases)according to the MCA recanalization.The independent risk factors affecting recanalization after intravenous thrombolysis were assessed by logistic regression analysis for patients'data,and ROC curve was used to analyze the value of revascularization after intravenous thrombolysis by 3D-pCASL technique.Results:The CBF values on the affected side at PLD=1.5,2.5 s were lower than those on the healthy side in 98 patients(both P<0.05).Compared with the recanalization group,patients in the non-recanalization group showed the elder age,higher percentage of extensive cerebral infarction and lower CBF values on the affected side at PLD=1.5,2.5 s(all P<0.05).And the multivariate logistic regression analysis showed that age and extensive cerebral infarction were the independent risk factors for recanalization after intravenous thrombolysis(all P<0.05),and the CBF values on the affected side at PLD=1.5,2.5 s were the independent protective factors(both P<0.05).ROC curve showed that the efficacy for recanalization of the combination of the above parameters was better than that of separate parameter(all P<0.05).Conclusion:The 3D-pCASL technique has high application value in assessing the vascular reserve capacity of patients with MCA occlusive cerebral infarction and evaluating the prognosis of intravenous thrombolysis.关键词
梗塞,大脑中动脉/磁共振成像/动脉自旋标记/脑血管储备能力/静脉溶栓Key words
Infarction,middle cerebral artery/Magnetic resonance imaging/Arterial spin labeling technique/Cerebrovascular reserve capacity/Intravenous thrombolysis分类
医药卫生引用本文复制引用
付娟,白萱,谢文娟,陈轶,陈媛媛,吴江..3D-pCASL技术对大脑中动脉闭塞性脑梗死患者脑血管储备能力及静脉溶栓治疗预后的评估价值[J].中国中西医结合影像学杂志,2026,24(1):45-49,5.基金项目
陕西省重点研发计划项目(2022SF-301). （2022SF-301）
