中国癌症防治杂志2025，Vol.17Issue(6)：747-754,8.DOI:10.3969/j.issn.1674-5671.2025.06.13
CAR-NK细胞疗法在腹部肿瘤中的研究进展
Research progress of CAR-NK cell therapy in abdominal tumors
摘要
Abstract
As an emerging immunotherapy modality,chimeric antigen receptor(CAR)-natural killer(NK)cell therapy demonstrates significant potential in tumor treatment,achieving a pivotal breakthrough from foundational research to clinical application,particu-larly in the treatment of abdominal malignancies.This article provides an overview of CAR-NK cell therapy and systematically summa-rizes the research progress in its application to abdominal tumors,including hepatocellular carcinoma(HCC),gastric cancer,colorectal can-cer,and pancreatic cancer.It also explores the potential of key receptors including HER2,MSLN,CEA,and EGFR in developing novel CAR-NK therapies.This aims to explore new treatment pathways for patients with abdominal tumors,improve their clinical prognosis,and promote the field of molecular oncology towards precision diagnosis and treatment.关键词
肝细胞癌/胃癌/结直肠癌/胰腺癌/CAR-NK细胞疗法/腹部肿瘤/精准医学Key words
Hepatocellular carcinoma/Gastric cancer/Colorectal cancer/Pancreatic cancer/CAR-NK cell therapy/Abdominal tumors/Precision medicine分类
医药卫生引用本文复制引用
牛旭东,王丙萍,韩晶晶,冀亚东,周杰,明星,高艳伟..CAR-NK细胞疗法在腹部肿瘤中的研究进展[J].中国癌症防治杂志,2025,17(6):747-754,8.基金项目
公立医院科研联合基金科技项目(2023GLLH0106) （2023GLLH0106）
内蒙古自治区科技计划项目(2022YFSH0055) （2022YFSH0055）
内蒙古自治区人民医院博士科研启动资金项目(2024BS04) （2024BS04）
内蒙古自治区卫生健康科技计划项目(2025WSJK007) （2025WSJK007）
