中国癌症防治杂志2025，Vol.17Issue(6)：755-762,8.DOI:10.3969/j.issn.1674-5671.2025.06.14
乳酸化修饰在癌症中的作用机制及靶向治疗研究进展
Mechanisms and advances in targeted therapeutic strategies of lactylation in cancer
摘要
Abstract
Lactylation is a novel post-translational modification,plays a crucial role in cancer development by regulating metabolic and epigenetic reprogramming,as well as the immunosuppressive tumour microenvironment.The interaction between lactylation and immune cells modulates tumor differentiation,immune responses,and drug sensitivity,highlighting its significant potential as a thera-peutic target.This review summarizes the molecular mechanisms of lactylation in cancer,its clinical research progress,and future therapeutic prospects.The aim is to promote innovative research in the development of tumor treatment targets,thereby accelerating the clinical application of lactylation-based treatments.关键词
乳酸化修饰/靶向治疗/肿瘤微环境/代谢重编程Key words
Lactylation/Targeted therapeutic/Tumor microenvironment/Metabolic reprogramming分类
医药卫生引用本文复制引用
林进权,赵志,王兴..乳酸化修饰在癌症中的作用机制及靶向治疗研究进展[J].中国癌症防治杂志,2025,17(6):755-762,8.基金项目
国家自然科学基金项目(82060561) （82060561）
广西自然科学基金项目(2018GXNSFBA050047) （2018GXNSFBA050047）
广西研究生教育创新计划项目(YCSW2022379) （YCSW2022379）
