中国中西医结合影像学杂志2026，Vol.24Issue(1)：80-85,6.DOI:10.3969/j.issn.1672-0512.2026.01.016
剪切波弹性成像在抑郁症合并肝功能异常患者肝纤维化评估中的应用
Application of shear wave elastography in evaluating liver fibrosis in patients with depression and abnormal liver function
摘要
Abstract
Objective:To investigate the application of shear wave elastography(SWE)in evaluating liver fibrosis in patients with depression and abnormal liver function.Methods:A total of 70 patients with depression and abnormal liver function(dysfunction group),70 patients without abnormal liver function(normal-function group)and 70 healthy subjects(control group)were selected.Three groups underwent SWE,blood routine,liver function(ALT,AST,GGT,total bilirubin,indirect bilirubin,albumin,etc.)and serum liver fibrosis(PC Ⅲ,C-Ⅳ,hyaluronic acid,laminin)examinations,and the corresponding liver fibrosis indicators(APRI,FIB-4,Forns index)were calculated.The differences and correlations of all indicators of each group and between pre-treatment and post-treatment in the dysfunction group were statistically analyzed.Results:Compared with the control group,the levels of total bilirubin,direct bilirubin,indirect bilirubin,ALT,AST and GGT before treatment in the dysfunction group were all increased(all P<0.05),and the levels of total bilirubin,indirect bilirubin,total cholesterol,triglycerides and BMI after treatment were increased(all P<0.05).In the dysfunction group,compared with pre-treatment,the levels of the total bilirubin,direct bilirubin,indirect bilirubin,ALT,AST,GGT after treatment were significantly decreased(all P<0.05),while the levels of total cholesterol,triglycerides and BMI were significantly increased(all P<0.05).Compared with the control group,the levels of FIB-4,APRI,Forns index,PC Ⅲ,laminin,C-Ⅳ,hyaluronic acid and Young's modulus before treatment in the dysfunction group were statistically higher,and the laminin level and Young's modulus after treatment were statistically higher(both P<0.05).In the dysfunction group,compared with pre-treatment,the levels of FIB-4,APRI,Forns index,PC Ⅲ,laminin,C-Ⅳ,hyaluronic acid,and Young's modulus were decreased after treatment(all P<0.05).Intra-physician ICC was 0.933(95％CI 0.831-0.976),and inter-physician ICC was 0.901(95％CI 0.798-0.931).Pearson correlation analysis showed that Young's modulus had a very strong correlation with laminin,ALT and AST,a strong correlation with hyaluronic acid,C-Ⅳ,PC Ⅲ,AST and BMI,and a weak correlation with total cholesterol and triglycerides(all P<0.01).Conclusion:The Young's modulus of SWE technology can quantitatively evaluate the liver fibrosis in patients with depression and abnormal liver function.关键词
超声检查/弹性成像技术/肝纤维化/抑郁症/肝纤维化血清学指标Key words
Ultrasonography/Elasticity imaging techniques/Liver fibrosis/Depression/Serum markers of liver fibrosis分类
医药卫生引用本文复制引用
刘娟,韦朝阳,何江涛,陈万明,孙红光..剪切波弹性成像在抑郁症合并肝功能异常患者肝纤维化评估中的应用[J].中国中西医结合影像学杂志,2026,24(1):80-85,6.基金项目
连云港市卫生科技项目(ZD202307) （ZD202307）
南京医科大学康达学院2023年度科研发展基金(KD2023KYJJ131). （KD2023KYJJ131）
