中国中药杂志2026，Vol.51Issue(2)：579-587,9.DOI:10.19540/j.cnki.cjcmm.20251014.501
口服中成药干预血管性痴呆的临床研究证据图分析
Analysis of clinical research evidence diagrams on intervention of vascular dementia with oral Chinese patent medicines
摘要
Abstract
This study aims to systematically retrieve and sort out the clinical research evidence of oral Chinese patent medicines in the treatment of vascular dementia(VaD)and understand the distribution and quality of the existing evidence in this field.PubMed,Web of Science,Cochrane Library,EMbase,CNKI,VIP,Wanfang,and SinoMed databases were retrieved from their establishment to November 5,2024.Evidence diagrams were used to comprehensively present the data distribution characteristics.A total of 211 pieces of literature were included,among which 176 were RCTs,11 were non-RCTs,3 were retrospective studies,1 was cohort study,17 were systematic reviews/Meta-analyses,and 3 were expert recommendations or consensuses.It involves 45 kinds of Chinese patent medicines.Among them,Ginkgo Leave Tablets/Capsules are the most widely used.Most of the research periods are 8-12 weeks,and the sample size is 51-100 cases.The main outcome indicators include clinical efficacy,cognitive function evaluation,quality of life evaluation,safety indicators,neurological function indicators,hemorheological indicators,etc.The literature quality of RCTs,non-RCTs,and systematic reviews/Meta-analyses are generally not high,and the quality level of evidence is relatively low.Most studies have shown that oral Chinese patent medicines have potential efficacy in the treatment of VaD,but there is a lack of high-quality clinical evidence.Chinese patent medicines have advantages in the treatment of VaD,but there is still a lack of high-quality studies.This suggests that in future clinical research,large-sample and multi-center RCTs need to be carried out.Meanwhile,clinical research design and reporting should be standardized in accordance with relevant guidelines or tools to explore the characteristic advantages of oral Chinese patent medicines in the treatment of VaD,select reasonable outcome indicators,and strive to improve the quality of clinical research in TCM.This will help standardize the research plan,produce advanced evidence-based medical evidence with rigor and scientificity,and provide strong support for the prevention and treatment of VaD with TCM.关键词
血管性痴呆/证据图/中成药/临床研究Key words
vascular dementia/evidence diagram/Chinese patent medicine/clinical research引用本文复制引用
韩瑾,孙永康,徐方飚,宋研博,吴易俊,王新志..口服中成药干预血管性痴呆的临床研究证据图分析[J].中国中药杂志,2026,51(2):579-587,9.基金项目
中医药传承与创新"百千万"人才工程(岐黄工程)岐黄学者项目(国中医药人教函[2018]284号) （岐黄工程）
河南省"双一流"创建学科中医学科学研究专项(HSRP-DFCTCM-2023-5-07,HSRP-DFCTCM-2023-8-29) （HSRP-DFCTCM-2023-5-07,HSRP-DFCTCM-2023-8-29）
河南省中医药科学院院属研究所2025年首批"揭榜挂帅"项目——河南省中医药科研专项(2025ZKY004) （2025ZKY004）
