中国中药杂志2026，Vol.51Issue(1)：1-9,9.DOI:10.19540/j.cnki.cjcmm.20251212.412
再论分子生药学——三十年,一个新起点
Molecular Pharmacognosy revisited:charting a new course after three decades
摘要
Abstract
Since its conceptual inception in 1995,Molecular Pharmacognosy has evolved over three decades from a nascent idea into a frontier interdisciplinary discipline characterized by a comprehensive theoretical system,mature methodologies,and extensive applications.This paper systematically reviews the significant milestones of this discipline in theoretical innovation,technical standardization,industrial application,and platform construction.It highlights breakthrough achievements in areas such as technical standards for the molecular identification of crude drugs,elucidation of the formation mechanisms of Dao-di herbs,establishment of conservation models for rare and endangered resources,and biosynthesis of active compounds.The paper further elucidates the evolutionary research paradigm of Molecular Pharmacognosy.Originating from phenomena observed in both the discipline and the industry,this paradigm advances through a progressive cycle of problem derivation—hypothesis presupposition—technical innovation—theoretical enrichment,driven by the dynamic interplay between theory and practice.Furthermore,the paper analyzes current challenges regarding the precision of molecular identification,the complex mechanisms of geo-authenticity,and the sustainable utilization of resources.Molecular Pharmacognosy is poised to integrate deeply with frontier technologies such as artificial intelligence,pan-omics,quantum computing,biomanufacturing,smart breeding,and gene editing.This integration will drive a revolutionary shift in the research paradigm from recognition and revelation to prediction and design.Ultimately,these achievements will mark a new phase defined by precision,systematization,and engineering,injecting fresh momentum into the modernization of TCM.关键词
分子生药学/学科演进/道地药材/人工智能/生物制造/智能育种Key words
Molecular Pharmacognosy/disciplinary evolution/Dao-di herbs/artificial intelligence/biomanufacturing/smart breeding引用本文复制引用
黄璐琦,郑汉,袁媛,郭娟..再论分子生药学——三十年,一个新起点[J].中国中药杂志,2026,51(1):1-9,9.基金项目
国家自然科学基金项目(82474040) （82474040）
中国中医科学院研究生课程思政建设项目(KCSZ24001) （KCSZ24001）
中央本级重大增减支项目(2060302) （2060302）
