中国中药杂志2026，Vol.51Issue(1)：10-18,9.DOI:10.19540/j.cnki.cjcmm.20251021.302
药物经鼻递送新技术及评价技术研究进展
Research progress on novel technologies and evaluation methods for nasal drug delivery
摘要
Abstract
Focused on the challenges in brain disease treatment and advancements in nose-to-brain delivery research,this article summarized current progress in nasal drug delivery research and proposed several novel evaluation models for nasal drug absorption.By reviewing five types of evaluation models-ex vivo animal tissue models,in situ perfusion models,in vivo pharmacokinetic models,in vitro cell models,and computational fluid dynamics model-it clarified the distinct advantages of nasal drug delivery compared to other administration routes.Furthermore,by outlining emerging nasal drug delivery technologies and irritation evaluation methods,it explored the cutting-edge directions of nose-to-brain delivery.This provides essential support for the selection of nose-to-brain delivery dosage forms and paves new paths for the advancement of nasal drug delivery.关键词
鼻腔给药/药物吸收评价模型/促鼻吸收新技术/刺激性评价Key words
nasal drug delivery/drug absorption evaluation models/novel nasal absorption enhancement technologies/irritation evaluation引用本文复制引用
李琳,杜慧慧,刘彦洵,樊箫雨,叶津宏,沈慧娟,李鹏跃,杜守颖..药物经鼻递送新技术及评价技术研究进展[J].中国中药杂志,2026,51(1):10-18,9.基金项目
国家中医管理局高水平重点学科-中药药剂学项目(zyyzdxk-2023272) （zyyzdxk-2023272）
国家自然科学基金项目(82274111,81803738) （82274111,81803738）
