中国中药杂志2026，Vol.51Issue(1)：19-31,13.DOI:10.19540/j.cnki.cjcmm.20251009.201
miRNA在骨性关节炎中的作用机制及中医药干预研究进展
Mechanisms of miRNA in osteoarthritis and research advances in traditional Chinese medicine intervention
摘要
Abstract
Osteoarthritis(OA)is a common degenerative joint disease characterized by cartilage degeneration,synovial inflammation,osteophyte formation,and joint space narrowing,seriously impairing patients' mobility and quality of life.The pathogenesis of OA is highly complex,involving multiple cell types and signaling pathways.Key pathological processes include abnormal chondrocyte function,sustained activation of inflammatory responses,and imbalances in apoptosis and autophagy.In recent years,microRNAs(miRNAs),small non-coding RNAs,have been recognized for their crucial roles in regulating gene expression and influencing the progression of various diseases.miRNAs exhibit important regulatory functions in OA-related processes such as inflammatory regulation,chondrocyte apoptosis and autophagy,extracellular matrix metabolism,and subchondral bone remodeling.Multiple specific miRNAs have been shown to be closely associated with the onset and progression of OA,demonstrating potential diagnostic and therapeutic value.Traditional Chinese medicine(TCM)is an important treatment approach for OA,offering advantages such as multi-component,multi-target,and multi-pathway regulation.Recent studies have shown that TCM single herbs,compound prescriptions,acupuncture,and moxibustion can upregulate or downregulate the expression of specific miRNAs,thereby intervening in their downstream target genes and related signaling pathways.This leads to anti-inflammatory and analgesic effects,inhibition of chondrocyte apoptosis,promotion of matrix synthesis,and cartilage repair.This review systematically summarizes the mechanisms of miRNAs in the progression of OA,with a focus on the latest research advances in TCM regulation of miRNAs to intervene in OA.The aim is to provide a theoretical basis and new insights for the early molecular diagnosis,targeted therapy,and modern research and clinical translation of TCM in OA.关键词
骨性关节炎/miRNA/中医药/研究进展Key words
osteoarthritis/miRNA/traditional Chinese medicine/research progress引用本文复制引用
周海东,陈虞文,罗晖,胡梁深,张凤婷,胡文涛,谢杰飞,卢姚宏,单记春,范少勇..miRNA在骨性关节炎中的作用机制及中医药干预研究进展[J].中国中药杂志,2026,51(1):19-31,13.基金项目
江西省重点研发计划项目(20202BBG73028) （20202BBG73028）
2024年江西省校级大学生创新创业训练计划项目(202410412281) （202410412281）
2024年江西省研究生创新专项资金项目(YC2024-B239) （YC2024-B239）
江西省教育厅科学技术研究项目(GJJ2200986) （GJJ2200986）
