中国中药杂志2026，Vol.51Issue(1)：32-39,8.DOI:10.19540/j.cnki.cjcmm.20251011.708
无菌动物模型在结直肠癌及中医药研究中的应用进展
Application progress of germ-free animal models in colorectal cancer and traditional Chinese medicine research
摘要
Abstract
Colorectal cancer(CRC)is a highly prevalent malignant tumor worldwide,and its occurrence and development are closely related to gut microbiota disturbance.The germ-free(GF)animal model,by providing a unique environment free of indigenous microorganisms,has become a tool for precisely dissecting the causal role and mechanism of the gut microbiota in the occurrence and development of CRC and the therapeutic mechanisms of pharmaceuticals.This review aims to systematically elaborate on the application progress of GF animal models in CRC research,with a focus on the key mechanisms by which specific microorganisms promote the occurrence and development of CRC revealed by this model.Furthermore,this review focuses on the research dynamics of TCM in this field and systematically expounds the application of GF models in the research of TCM against CRC.Through in-depth analysis of the GF animal models of CRC,it is possible to develop precise diagnostic and therapeutic strategies based on TCM and the microbiome in the future,providing new directions and ideas for the prevention and treatment of CRC.关键词
无菌动物/肠道菌群/中医药/结直肠癌Key words
germ-free animals/gut microbiota/traditional Chinese medicine/colorectal cancer引用本文复制引用
钱紫星,李家旋,饶显俊,黄国栋,刘然,魏玮..无菌动物模型在结直肠癌及中医药研究中的应用进展[J].中国中药杂志,2026,51(1):32-39,8.基金项目
国家中医药传承创新团队项目(ZYYCXTD-C-202210) （ZYYCXTD-C-202210）
国家自然科学基金区域创新发展联合基金项目(U22A20375) （U22A20375）
北京市重大疑难疾病中西医协同攻关项目(2023BJSZDYNJBXTGG-016) （2023BJSZDYNJBXTGG-016）
