中国中药杂志2026，Vol.51Issue(1)：40-49,10.DOI:10.19540/j.cnki.cjcmm.20251011.703
假马齿苋活性成分及其衍生物对神经系统疾病的保护作用研究进展
Research progress in neuroprotective effects of Bacopa monnieri active components and derivatives in neurological disorders
摘要
Abstract
Bacopa monnieri,a plant of Scrophulariaceae,has a long history of medicinal use and is recognized as a traditional medicinal herb in multiple countries.Neurological disorders,due to their extensive damage to neural functions,have become a major public health challenge and garnered worldwide attention.In ancient times,B.monnieri was documented for treating cognitive and memory impairments.Recent studies have elucidated its pharmacological mechanisms and therapeutic targets underpinning the neuroprotective effect.However,the molecular mechanisms of its active ingredients have not been systematically summarized.This study is the first to integrate the target sites of its core ingredients across multiple categories of neurological disorders.It summarizes the pharmacological mechanisms of B.monnieri as well as its active ingredients and derivatives in various neurological diseases,which exert neuroprotective effects through multi-target interactions.This paper provides novel strategies for developing botanical drugs targeting diseases like Alzheimer's and epilepsy and aims to offer evidence-based guidance for the development and application of B.monnieri in functional foods,health supplements,and pharmaceuticals.关键词
假马齿苋/活性成分/神经系统疾病/神经退行性疾病/神经发育障碍性疾病/药理作用Key words
Bacopa monnieri/active ingredients/neurological disorders/neurodegenerative diseases/neurodevelopmental disor-ders/pharmacological effects引用本文复制引用
梁绿圆,魏炳琦,马丙祥,崔洁琼,曹佳蕾,赵紫琳,祁翼帆,王燕华,方上明,董帅彬,王云凯,谭祥汉..假马齿苋活性成分及其衍生物对神经系统疾病的保护作用研究进展[J].中国中药杂志,2026,51(1):40-49,10.基金项目
国家自然科学基金项目(81973904) （81973904）
国家自然科学基金青年科学基金项目(81904252) （81904252）
国家中医药传承创新中心科研专项(2023ZXZX1060) （2023ZXZX1060）
河南省特色骨干学科中医学学科建设项目(STG-ZYX06-202144,STG-ZYXKY-2020023) （STG-ZYX06-202144,STG-ZYXKY-2020023）
2023年度河南省中医学"双一流"创建科学研究专项课题(HSRP-DFCTCM-2023-2-08) （HSRP-DFCTCM-2023-2-08）
河南省中医药科学研究专项(2023ZY2057) （2023ZY2057）
河南省重点研发与推广专项(科技攻关项目)(232102311208) （科技攻关项目）
