中国中药杂志2026，Vol.51Issue(1)：50-55,6.DOI:10.19540/j.cnki.cjcmm.20250929.801
中医药调节血管内皮细胞间质转化抗动脉粥样硬化研究进展
TCM regulates endothelial-to-mesenchymal transition in treatment of atherosclerosis:a review
摘要
Abstract
Endothelial-to-mesenchymal transition(EndMT)is a process in which endothelial cells lose specific markers and acquire a mesenchymal phenotype under pathological stimulation,contributing to the occurrence and progression of atherosclerosis(AS).Recent studies have shown that TCM,with its unique advantages of holism and treatment based on syndrome differentiation,can inhibit AS by regulating EndMT-related signaling pathways at multiple levels,through multiple pathways and targets.This article systematically reviews the mechanisms of EndMT in AS,as well as the research progress of TCM monomers and compounds in counteracting AS via EndMT intervention,providing new ideas and a scientific basis for the prevention and treatment of AS with TCM.关键词
动脉粥样硬化/内皮间质转化/中医药/研究进展Key words
atherosclerosis/endothelial-to-mesenchymal transition/traditional Chinese medicine/research progress引用本文复制引用
张雪妍,段盈竹,于游,张欢,王娇丹,耿新冉,于睿..中医药调节血管内皮细胞间质转化抗动脉粥样硬化研究进展[J].中国中药杂志,2026,51(1):50-55,6.基金项目
国家自然科学基金项目(82274494) （82274494）
辽宁省博士科研启动基金计划项目(2025-BS-0710) （2025-BS-0710）
