中国药房2026，Vol.37Issue(2)：149-154,6.DOI:10.6039/j.issn.1001-0408.2026.02.03
PCSK9抑制剂用于高胆固醇血症的临床快速评价
Clinical rapid evaluation of proprotein convertase subtilisin/kexin type 9 inhibitors for hypercholesterolemia
摘要
Abstract
OBJECTIVE To conduct a clinical rapid evaluation of the marketed proprotein convertase subtilisin/kexin type 9(PCSK9)inhibitors in China,including evolocumab,tafolecimab,recaticimab,ebronucimab,ongericimab and inclisiran.METHODS Based on the Rapid Guide for Drug Evaluation and Selection in Chinese Medical Institutions(second edition),drug instructions,clinical diagnosis and treatment guidelines,and literature for six drugs were retrieved from CNKI,Wanfang Data,VIP,PubMed,Embase,Cochrane Library and related official websites.The clinical rapid evaluation was conducted from five aspects:pharmaceutical characteristics,effectiveness,safety,economy,and other attributes.RESULTS The pharmaceutical characteristics,effectiveness,safety,economy,other attributes,and total score of evolocumab scored 24,27,15.7,10,5.3,and 82 points,respectively.Tafolecimab scored 23.5,23,11.5,9.97,4.6,and 72.57 points,respectively.Recaticimab scored 20.5,22,15.5,6.37,3.5,and 67.87 points.Ebronucimab scored 20,23,11,6.48,3.5,and 63.98 points.Ongericimab scored 20.5,23,8.5,4.83,3.5,and 60.33 points.Inclisiran scored 25.5,24,13,6.48,5,and 73.98 points.CONCLUSIONS Evolocumab is the optimal choice for treating hypercholesterolemia and is recommended as the first-line option.Tafolecimab is the second-line option,and recaticimab is suitable for patients who are sensitive to drug adverse reactions.Inclisiran is suitable for patients with poor compliance.Ebronucimab and ongericimab are weakly recommended due to their later market introduction.Clinicians should make individualized drug selections based on factors such as patient risk level and compliance requirements.关键词
PCSK9抑制剂/依洛尤单抗/托莱西单抗/瑞卡西单抗/伊努西单抗/昂戈瑞西单抗/英克司兰/高胆固醇血症/快速评价Key words
PCSK9 inhibitors/evolocumab/tafolecimab/recaticimab/ebronucimab/ongericimab/inclisiran/hypercho-lesterolemia/rapid evaluation分类
医药卫生引用本文复制引用
姚芯,康凤娇,尹琪楠,韩丽珠,边原..PCSK9抑制剂用于高胆固醇血症的临床快速评价[J].中国药房,2026,37(2):149-154,6.基金项目
四川省第二批省级科技计划项目(No.2022NSFSC0-818) （No.2022NSFSC0-818）
中关村精准医学基金会临床科研项目(No.202412-0021) （No.202412-0021）
