中国药房2026，Vol.37Issue(2)：155-160,6.DOI:10.6039/j.issn.1001-0408.2026.02.04
蠲哮汤改善支气管哮喘的机制研究
Study on the mechanism of Juanxiao decoction in improving bronchial asthma
摘要
Abstract
OBJECTIVE To investigate the potential mechanism by which Juanxiao decoction improves bronchial asthma(hereinafter referred to as"asthma")based on the nucleotide-binding domain leucine-rich repeat and pyrin domain-containing receptor 3(NLRP3)inflammasome signaling pathway.METHODS Female SD rats were randomly assigned to normal group,model group and Juanxiao decoction low-,medium-and high-dose groups(0.36,0.72 and 1.44 g/kg,calculated based on crude drug weight),as well as positive control group(Dexamethasone acetate tablets,0.2 mg/kg),with 10 rats in each group.Except for the normal group,asthma models were established in the remaining groups via intraperitoneal injection of ovalbumin combined with aluminum hydroxide,followed by nebulized inhalation of ovalbumin.On day 14 of the experiment,rats in each group received intragastric administration of the corresponding solution or normal saline,once a day,for 7 consecutive days.Following the final administration,the following parameters were measured in each group:lung function indexes(forced vital capacity,forced expiratory volume in 0.3 second,peak expiratory flow),serum levels of inflammatory markers(interleukin-1β,interleukin-18),and the percentages of inflammatory cells(lymphocytes,eosinophils,neutrophils)in bronchoalveolar lavage fluid.Histopathological changes in lung tissue were observed,and the protein and mRNA expressions of nuclear factor-kappa B(NF-κ B),NLRP3 and caspase-1 in lung tissue were detected.RESULTS Compared with the normal group,pathological changes such as alveolar wall thickening and inflammatory cell infiltration were observed in rats in the model group.All pulmonary function indicators were significantly reduced in rats in the model group and the administration groups.The levels of inflammatory markers,the percentages of inflammatory cells,and the protein and mRNA expressions of NF-κB,NLRP3 and caspase-1 were significantly elevated or up-regulated(P＜0.05).Compared with the model group,pathological changes in rats in each dosage group of Juanxiao decoction were significantly alleviated,and all quantitative indicators showed dose-dependent improvements(P＜0.05).CONCLUSIONS Juanxiao decoction can reduce airway inflammatory responses in asthmatic rats,alleviate lung function impairment,and improve pathological changes such as inflammatory cell infiltration.Those effects may be related to the inhibition of the NLRP3 inflammasome signaling pathway.关键词
蠲哮汤/支气管哮喘/NLRP3炎症小体信号通路Key words
Juanxiao decoction/bronchial asthma/NLRP3 inflammasome signaling pathway分类
医药卫生引用本文复制引用
曹邦卿,喻强强,刘美年,吴支喜,曾丽珍,童梦瑶,邓云华,薛汉荣..蠲哮汤改善支气管哮喘的机制研究[J].中国药房,2026,37(2):155-160,6.基金项目
国家自然科学基金项目(No.82460876) （No.82460876）
江西省自然科学基金项目(No.20242BAB25559) （No.20242BAB25559）
江西省中医药管理局科技计划项目(No.2024B0799) （No.2024B0799）
