中国中药杂志2026，Vol.51Issue(1)：83-91,9.DOI:10.19540/j.cnki.cjcmm.20250925.301
煎煮方式对肉桂-黄连药对超分子的物质相态和生物活性的影响
Effect of decoction method on phase state and biological activity of Cinnamomi Cortex-Coptidis Rhizoma supramolecular
摘要
Abstract
Based on supramolecular chemistry of TCM,this study investigated the interaction between Cinnamomi Cortex-Coptidis Rhizoma herb pair and compared phase states and bioactivity differences under different decoction methods(co-decoction vs individual decoction followed by mechanical mixing).Phase state variations were observed macroscopically and through turbidimetry.The herb interaction was analyzed using isothermal titration calorimetry,UV and IR spectroscopy.Particle size differences were determined by dynamic light scattering and scanning electron microscopy(SEM).Antimicrobial activity was evaluated through broth dilution,plate coating,live/dead staining,and SEM.Component analysis was conducted using UPLC-MS/MS.Results revealed distinct supramolecular structures in Cinnamomi Cortex-Coptidis Rhizoma decoctions,with co-decoction showing more stable macroscopic phase states.The interaction was a spontaneous exothermic reaction driven by both entropy and enthalpy.UV and IR spectra revealed co-decoction demonstrated more sufficient molecular interactions,more stable supramolecular structures,and smaller particle sizes with a more centralized distribution.In addition,co-decoction resulted in higher berberine and coptisine content and stronger inhibitory activity against Staphylococcus aureus compared to mechanical mixtures.These findings indicated that co-decoction produced Cinnamomi Cortex-Coptidis Rhizoma supramolecular systems with more homogeneous phase states,enhanced measurable coptisine and berberine content,and superior antibacterial efficacy.关键词
肉桂/黄连/超分子/煎煮方式/生物活性Key words
Cinnamomi Cortex/Coptidis Rhizoma/supramolecular/decoction method/bioactivity引用本文复制引用
徐冉,黄雪梅,王鹏龙,王志家,林晓钰,魏吉昌,赵一航,谭心如,汪志霞,张留洋,王泓力..煎煮方式对肉桂-黄连药对超分子的物质相态和生物活性的影响[J].中国中药杂志,2026,51(1):83-91,9.基金项目
国家自然科学基金项目(82474059) （82474059）
中央高校基金科研业务项目(2023-JYB-JBZD-049,2022-XJ-KYQD-008) （2023-JYB-JBZD-049,2022-XJ-KYQD-008）
国家级高层次青年人才支持计划项目 （）
