中国药房2026，Vol.37Issue(2)：204-209,6.DOI:10.6039/j.issn.1001-0408.2026.02.12
亚麻醉剂量艾司氯胺酮对腹腔镜胆囊切除术患者术后焦虑及恢复的影响
Effects of subanesthetic dose of esketamine on postoperative anxiety and recovery in patients undergoing laparoscopic cholecystectomy
摘要
Abstract
OBJECTIVE To investigate the effects of subanesthetic dose of esketamine on postoperative anxiety and recovery in patients undergoing laparoscopic cholecystectomy.METHODS A total of 200 patients scheduled for laparoscopic cholecystectomy at Suzhou Ninth Hospital Affiliated to Soochow University from January 2023 to December 2024 were randomly assigned to control group(n=100)and observation group(n=100).One minute before the initiation of anesthesia,patients in the control group received intravenous injections of Propofol emulsion injection,Sufentanil citrate injection,and Succinylcholine chloride injection.On this basis,patients in the observation group received an intravenous injection of Esketamine hydrochloride injection.The anxiety status of patients in both groups was compared,along with their general intraoperative conditions(including sufentanil dosage,duration of pneumoperitoneum,operative time,anesthesia time,and extubation time),postoperative recovery,incidence of adverse reactions,and the need for dezocine rescue analgesia.Heart rate and mean arterial pressure,entropy index(state entropy and response entropy),inflammatory marker levels[interleukin-6(IL-6)and C-reactive protein(CRP)],numerical rating scale(NRS)for pain intensity were compared between the two groups at different time points.RESULTS No significant differences were found between the two groups in pneumoperitoneum duration,operative time,anesthesia time,extubation time,incidence of postoperative dry mouth,entropy index or length of stay in the post-anesthesia care unit(P＞0.05).Compared with the control group,the observation group showed significantly lower postoperative STAI-S scores,reduced intraoperative sufentanil consumption,decreased incidence of postoperative nausea,vomiting,and shivering,the need for dezocine rescue analgesia,as well as lower plasma IL-6 and CRP levels at 24 h after surgery,and NRS(P＜0.05).The heart rate and mean arterial pressure of patients in the observation group at the start of surgery,end of surgery,and during extubation were all significantly higher than those in the control group(P＜0.05).CONCLUSIONS Subanesthetic dose of esketamine can effectively alleviate postoperative anxiety,reduce intraoperative opioid consumption,suppress postoperative inflammatory response,relieve postoperative pain,and promote recovery in patients undergoing laparoscopic cholecystectomy.关键词
艾司氯胺酮/焦虑/术后恢复/全身麻醉/亚麻醉剂量/腹腔镜胆囊切除术Key words
esketamine/anxiety/postoperative recovery/general anesthesia/subanesthetic dose/laparoscopic cholecystectomy分类
医药卫生引用本文复制引用
钟章珍,张超,郑显,徐婷,王洁,曹晖,周兴根,李辉,赵嘉诚,刘慧..亚麻醉剂量艾司氯胺酮对腹腔镜胆囊切除术患者术后焦虑及恢复的影响[J].中国药房,2026,37(2):204-209,6.基金项目
江苏省教育厅高校重点实验室开放课题(No.XZSYSKF2020043) （No.XZSYSKF2020043）
苏州市科技计划项目(No.SKY2023099) （No.SKY2023099）
苏州市医学会"麻醉医星"科技项目(No.2024MZ-M02) （No.2024MZ-M02）
苏州市吴江区"科教兴卫"项目(No.WWK202501) （No.WWK202501）
