中山大学学报（医学科学版）2026，Vol.47Issue(1)：1-10,10.DOI:10.11714/jsysu.med.YX20250163
广州管圆线虫感染致病机制及研究进展
Research Progress on the Pathogenic Mechanisms and Prevention of Angiostrongylus cantonensis Infection
摘要
Abstract
Angiostrongyliasis cantonensis is a major food-borne zoonotic parasitic disease caused by Angiostrongylus cantonensis(AC),representing a significant threat to human health.Upon infection,AC larvae penetrate the intestinal wall and migrate through the liver and lungs to the central nervous system(CNS).This process leads to various pathological conditions characterized by pronounced eosinophilia,most notably eosinophilic meningitis,encephalitis,ocular complications,and pneumonia.Elucidating the mechanisms of AC-induced tissue damage and its molecular pathogenesis is essential for the prevention and effective treatment of angiostrongyliasis.This review systematically synthesizes recent advances from multi-omics,pathology,and immunology to explore the mechanisms of infection,multi-organ pathogenesis,and host immune regulation.The goal is to provide a theoretical framework for enhancing diagnostic precision,optimizing clinical treatments,and strengthening epidemiological control of this disease.关键词
广州管圆线虫/嗜酸性粒细胞性脑炎/致病机制/免疫调节/多组学Key words
Angiostrongylus cantonensis/eosinophilia meningitis/pathogenesis/immunomodulation/multi-omics分类
医药卫生引用本文复制引用
孙希,吴忠道..广州管圆线虫感染致病机制及研究进展[J].中山大学学报（医学科学版）,2026,47(1):1-10,10.基金项目
国家重点研发项目(2024YFC2309700) （2024YFC2309700）
国家自然科学基金(82272361,82161160343),广东省自然科学基金(2024A1515010615),广东省重点研发项目(2022B1111030002) （82272361,82161160343）
