中山大学学报（医学科学版）2026，Vol.47Issue(1)：43-54,12.DOI:10.11714/jsysu.med.YX20250135
hiPSC在心血管疾病机制和转化应用中的研究进展
Human Induced Pluripotent Stem Cells in Cardiovascular Disease:Mechanisms and Translational Applications
摘要
Abstract
Cardiovascular diseases are the leading cause of mortality worldwide,yet their pathogenic mechanisms and functional repair remain incompletely understood.The emergence and development of human induced pluripotent stem cells(hiPSC)have provided unprecedented opportunities for cardiovascular disease research,and markedly enhanced our understanding of cardiovascular disease mechanisms.This review summarizes recent advances in cardiovascular cells and cardiac organoids derived from hiPSC,and presents our team's related research findings in this field.It highlights the induction and differentiation of hiPSC-derived cardiomyocytes and non-myocytes,as well as their roles in disease modeling,functional repair,drug screening,and mechanistic investigation.Furthermore,the current applications of hiPSC-derived cardiac organoids in cardiovascular disease research are also discussed.关键词
人诱导多能干细胞/心血管疾病/心肌细胞/非心肌细胞/心脏类器官Key words
human induced pluripotent stem cell/cardiovascular diseases/cardiomyocytes/non-myocytes/cardiac organoids分类
医药卫生引用本文复制引用
黄亮,向秋玲..hiPSC在心血管疾病机制和转化应用中的研究进展[J].中山大学学报（医学科学版）,2026,47(1):43-54,12.基金项目
国家重点研发计划项目(2024YFE0217400) （2024YFE0217400）
国家自然科学基金(82470367,82272164) （82470367,82272164）
广东省自然科学基金(2024A1515013135) （2024A1515013135）
